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- W2013794417 abstract "Respiratory syncytial virus (RSV) is the most frequent aetiologic agent that causes bronchiolitis and lower respiratory tract infection in infants. These infections may be severe and even life-threatening in selected high-risk populations. Traditional, well-established, high-risk populations are preterm infants with or without chronic lung disease and children with congenital heart disease. For these children, RSV prophylaxis using palivizumab, a monoclonal anti-RSV humanised antibody against the F-protein of RSV, has proven safe and efficacious in preventing RSV-related hospitalisation. Recently, a number of rare medical conditions have been associated with the risk of severe RSV infections. Evidence of safety and efficacy of RSV prophylaxis in these populations is lacking. Given the low incidence of these conditions, randomised trials are not feasible. A practical, opinion-based approach to this dilemma is offered in this paper. It is proposed that these rare disorders may qualify for RSV prophylaxis if the association between a specific condition and the risk of severe RSV infection is confirmed in at least 3 independent publications, of which at least 1 includes a prospective cohort study. To facilitate pharmaco-economic analyses, at least one of the three studies must also report on the absolute risk of severe RSV infection in the specified illness. The authors believe that qualification criteria will enable caregivers to target RSV prophylaxis more effectively in children with rare conditions and the proposed approach provides direction for future epidemiological studies on the risk of severe RSV infection in children with these uncommon, medical illnesses." @default.
- W2013794417 created "2016-06-24" @default.
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- W2013794417 creator A5068706267 @default.
- W2013794417 date "2012-05-01" @default.
- W2013794417 modified "2023-10-16" @default.
- W2013794417 title "High risk for RSV bronchiolitis in late preterms and selected infants affected by rare disorders: a dilemma of specific prevention" @default.
- W2013794417 cites W1662150385 @default.
- W2013794417 cites W1965985689 @default.
- W2013794417 cites W1966099212 @default.
- W2013794417 cites W1966145729 @default.
- W2013794417 cites W1971987845 @default.
- W2013794417 cites W1974893479 @default.
- W2013794417 cites W1974973118 @default.
- W2013794417 cites W1978110494 @default.
- W2013794417 cites W1978492270 @default.
- W2013794417 cites W1979156497 @default.
- W2013794417 cites W1983495472 @default.
- W2013794417 cites W1986189079 @default.
- W2013794417 cites W1986691227 @default.
- W2013794417 cites W1988711026 @default.
- W2013794417 cites W1991257630 @default.
- W2013794417 cites W1994149977 @default.
- W2013794417 cites W1994239852 @default.
- W2013794417 cites W1995722533 @default.
- W2013794417 cites W1996521384 @default.
- W2013794417 cites W1997883562 @default.
- W2013794417 cites W1998694339 @default.
- W2013794417 cites W2000718589 @default.
- W2013794417 cites W2001409963 @default.
- W2013794417 cites W2002239252 @default.
- W2013794417 cites W2003757677 @default.
- W2013794417 cites W2007051807 @default.
- W2013794417 cites W2007744968 @default.
- W2013794417 cites W2013803040 @default.
- W2013794417 cites W2015017103 @default.
- W2013794417 cites W2015593907 @default.
- W2013794417 cites W2016056885 @default.
- W2013794417 cites W2018672014 @default.
- W2013794417 cites W2019275987 @default.
- W2013794417 cites W2020271045 @default.
- W2013794417 cites W2020467334 @default.
- W2013794417 cites W2021268034 @default.
- W2013794417 cites W2022396525 @default.
- W2013794417 cites W2023227014 @default.
- W2013794417 cites W2025190283 @default.
- W2013794417 cites W2028783595 @default.
- W2013794417 cites W2029503764 @default.
- W2013794417 cites W2029999029 @default.
- W2013794417 cites W2031692211 @default.
- W2013794417 cites W2032027078 @default.
- W2013794417 cites W2033052186 @default.
- W2013794417 cites W2036877259 @default.
- W2013794417 cites W2039061193 @default.
- W2013794417 cites W2046093522 @default.
- W2013794417 cites W2048204433 @default.
- W2013794417 cites W2048484118 @default.
- W2013794417 cites W2049928680 @default.
- W2013794417 cites W2049947933 @default.
- W2013794417 cites W2049951286 @default.
- W2013794417 cites W2051131055 @default.
- W2013794417 cites W2056291443 @default.
- W2013794417 cites W2056346492 @default.
- W2013794417 cites W2056736701 @default.
- W2013794417 cites W2056843730 @default.
- W2013794417 cites W2057352870 @default.
- W2013794417 cites W2057517469 @default.
- W2013794417 cites W2058758881 @default.
- W2013794417 cites W2061281474 @default.
- W2013794417 cites W2063601276 @default.
- W2013794417 cites W2063630372 @default.
- W2013794417 cites W2067374081 @default.
- W2013794417 cites W2068377502 @default.
- W2013794417 cites W2068856936 @default.
- W2013794417 cites W2074592665 @default.
- W2013794417 cites W2076902286 @default.
- W2013794417 cites W2081412202 @default.
- W2013794417 cites W2082185509 @default.
- W2013794417 cites W2082299086 @default.
- W2013794417 cites W2083356680 @default.
- W2013794417 cites W2084054844 @default.
- W2013794417 cites W2084562899 @default.
- W2013794417 cites W2086233404 @default.
- W2013794417 cites W2086891888 @default.
- W2013794417 cites W2088106926 @default.
- W2013794417 cites W2089098888 @default.
- W2013794417 cites W2091701806 @default.
- W2013794417 cites W2091726854 @default.
- W2013794417 cites W2095518405 @default.
- W2013794417 cites W2101376207 @default.
- W2013794417 cites W2104645296 @default.
- W2013794417 cites W2107841228 @default.
- W2013794417 cites W2108488933 @default.