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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013803904> ?p ?o ?g. }

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• W2013803904 abstract "The parental cells of the TSA murine mammary adenocarcinoma (TSA-pc) were transfected with both the interferon-gamma (IFN-y) gene and the cytosine deaminase (CD) suicide gene to obtain a therapeutic vaccine active against TSA-pc lung metastases. Even in the absence of treatment with the prodrug 5-fluorocytosine (5-FC), the local growth of double transfectants (CD-y clones) was inhibited by a marked recruitment of granulocytes and macrophages. In mice harboring TSA-pc micrometastases, therapeutic vaccination with either IFN-gamma or CD single transfectants reduced the number of lung nodules, whereas CD-gamma double transfectants abrogated metastasis growth in up to 80% of mice. Treatment of mice with 5-FC did not alter the curative efficacy of CD-gamma double-transfectant cells. By contrast, in mice vaccinated with CD single-transfectant cells, 5-FC treatment caused a significant loss of their curative activity. Host T cells played an active role in the cure of lung metastases, because vaccination of nude mice with CD-gamma cells was uneffective." @default.
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• W2013803904 date "1998-01-20" @default.
• W2013803904 modified "2023-10-17" @default.
• W2013803904 title "The Immune Response Elicited by Mammary Adenocarcinoma Cells Transduced with Interferon-<i>γ</i>and Cytosine Deaminase Genes Cures Lung Metastases by Parental Cells" @default.
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• W2013803904 doi "https://doi.org/10.1089/hum.1998.9.2-217" @default.
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