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- W2013804934 abstract "The lipoproteins were first discovered in the late 1920s by Macheboeuf who used ammonium sulfate precipitation to separate and fractionate the 1ipoproteins.l In the 194Os, they were further studied, first by Oncley and his group at Harvard, using Cohn fractionation, and later by Gofman and associates at the Donner Laboratory in California. Gofman et a12 used analytical ultracentrifugation to separate the lipoproteins based on their rate of flotation in the ultracentrifuge. In the mid-1950s, Havel, Eder and Bragdon introduced preparative ultracentrifugation, which remains the classic way of separating the plasma lipoproteins. In the 196Os, Hatch and Lees used albumin in buffer, which resulted in a much cleaner separation of the lipoproteins on paper electrophoresis. This technique was subsequently adopted by Fredrickson, Levy and Lees,4 who used electrophoresis along with preparative ultracentrifugation and heparin manganese precipitation as the basis of a system for phenotyping the plasma lipoproteins. The introduction of a simple system for classifying plasma lipoprotein disorders based on phenotypes helped to generate an outburst of interest in research in the plasma lipoprotein field (Table I). More recently, zonal centrifugation for dividing lipoprotein classes into subgroups and the use of monoclonal antibodies to identify apolipoproteins have been introduced. The plasma lipoproteins are macromolecular complexes held together by noncovalent, primarily hydrophobic, forces, and serve as the carriers of lipid in plasma. With the exception of the fatty acids, which are carried by albumin, all of the plasma lipids are transported in association with plasma lipoproteins. One of the functions of this group of particles is to serve as a detergent to solubilize and protect the water-insoluble lipids-cholesteryl esters and triglycerides-as they are carried in the blood. The major lipid components of the plasma lipoproteins are phospho-" @default.
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- W2013804934 date "1985-12-01" @default.
- W2013804934 modified "2023-10-12" @default.
- W2013804934 title "Classification and structure of lipoproteins" @default.
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- W2013804934 doi "https://doi.org/10.1016/0002-9149(85)90467-9" @default.
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