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- W2013804962 abstract "1. Intravenous injection of paeoniflorin, a glycoside purified from the root of Paeonia lactiflora, reversed guanethidine-induced hypotension in Wistar rats. 2. Pretreatment with the adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine inhibited this effect of paeoniflorin in a dose-dependent manner. 3. The action of paeoniflorin was not modified by 8-(p-sulfophenyl)theophylline, the polar antagonist of the adenosine A1 receptor, which is not able to enter the central nervous system. 4. We conclude that paeoniflorin can reverse guanethidine-induced hypotension via activation of adenosine A1 receptors in the brain of Wistar rats." @default.
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- W2013804962 modified "2023-10-17" @default.
- W2013804962 title "PAEONIFLORIN REVERSES GUANETHIDINE-INDUCED HYPOTENSION VIA ACTIVATION OF CENTRAL ADENOSINE A1 RECEPTORS IN WISTAR RATS" @default.
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- W2013804962 doi "https://doi.org/10.1046/j.1440-1681.1999.03132.x" @default.
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