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• W2013804985 abstract "There has been increasing interest in developing bioadhesive nanoparticles due to their great potential as carriers for therapeutics in oral drug delivery systems. Despite decades of research, such a system still has not been successfully implemented. This paper demonstrates the enormous potential of such engineered systems: the incorporation of a bioadhesive coating, poly(butadiene-maleic anhydride-co-L-DOPA) (PBMAD), to non-bioadhesive nanospheres resulted in an enhancement of particle uptake in the small intestine from 5.8±1.9% to 66.9±12.9%. Direct correlation was obtained between bulk tensile strength, in vitro binding to everted intestinal sacs and quantitative in vivo uptake; this data suggests that bulk properties of polymers can be used to predict bioadhesive properties of nano- and microparticles. The differential distribution of the nanospheres to various tissues following uptake suggests surface chemistry plays a significant role in their localization within the body. The results of these studies provide strong support for the use of bioadhesive polymers to enhance nano- and micro-particle uptake from the small intestine for oral drug delivery." @default.
• W2013804985 created "2016-06-24" @default.
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• W2013804985 date "2013-09-01" @default.
• W2013804985 modified "2023-10-10" @default.
• W2013804985 title "Can bioadhesive nanoparticles allow for more effective particle uptake from the small intestine?" @default.
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• W2013804985 doi "https://doi.org/10.1016/j.jconrel.2013.05.043" @default.
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