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- W2013806472 abstract "Benzohydroximinoyl chlorides are useful precursors to nitrile oxides used in the preparation of various heterocycles via 1,3-dipolar cycloadditions. These intermediates are typically accessed by oxidation of aldoximes using N-chlorosuccinimide. This simple and efficient reaction is highly exothermic and a significant induction period can be observed. The potential for a sudden and significant heat release makes large-scale reactions difficult to control and potentially hazardous. Herein we describe a thermal analysis of this reaction to determine the heat flow in the presence of common additives to determine the most effective means of safe scale-up. Of the additives screened, aqueous HCl consistently avoided an induction period and enabled a dose-controlled process to be developed." @default.
- W2013806472 created "2016-06-24" @default.
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- W2013806472 date "2010-05-21" @default.
- W2013806472 modified "2023-10-03" @default.
- W2013806472 title "Safe and Scaleable Oxidation of Benzaldoximes to Benzohydroximinoyl Chlorides<sup>†</sup>" @default.
- W2013806472 doi "https://doi.org/10.1021/op100013m" @default.
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