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- W2013807834 abstract "Extracellular superoxide production in the Chinese hamster CCL39 fibroblast cell line was detected by direct counting of luminol-enhanced chemiluminescence in the presence of horseradish peroxidase (HRP). This superoxide production, which is directly related to cell density, can be inhibited by diphenylene iodonium, a specific inhibitor of NADPH-oxidase. The O − 2 generation is transiently inhibited following exposure of the cells to elevated temperatures. To study the possible relationship between HSP27 and its modulation of NADPH-oxidase activity we measured the generation of O − 2 activity in CCL39 cells containing either the gene coding for human HSP27 or a mutant form of this gene leading to HSP27 unable to be phosphorylated. Cells with the enhanced expression of normal human HSP27 as well as the non-phosphorylatable protein exhibited a 20-fold higher superoxide production than control CCL39 cells. Furthermore, we demonstrate that accumulation of normal HSP27 appears to play a role in prevention of NADPH-oxidase inhibition by heat." @default.
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- W2013807834 date "1996-10-01" @default.
- W2013807834 modified "2023-10-18" @default.
- W2013807834 title "Enhancement of Superoxide Production and Protection against Heat Shock by HSP27 in Fibroblasts" @default.
- W2013807834 doi "https://doi.org/10.1006/bbrc.1996.1590" @default.
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