FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013809085> ?p ?o ?g. }

• W2013809085 endingPage "1368" @default.
• W2013809085 startingPage "1359" @default.
• W2013809085 abstract "Studies have demonstrated that the induction of oxidative stress may be involved in oxidative DNA damage. The present study examined and assessed the hydrogen peroxide (H 2 O 2 )-mediated DNA damage in human tumor KB cells and also assessed the ability of Moringa oleifera leaf extracts to inhibit the oxidative damage. H 2 O 2 imposed a stress on the membrane lipids which was quantified by the extent of thiobarbituric acid reactive substances (TBARS) formed. The leaf extracts caused a very significant inhibition of the extent of LPO formation and enhanced the activity of antioxidative enzymes such as superoxide dismutase (SOD) and catalase (CAT) in KB cells. The comet assay was employed to study the DNA damage and its inhibition by the leaf extracts. H 2 O 2 caused a significant increase in the number of cells bearing comets, resulting in significant DNA damage. The leaf extracts significantly reduced the incidence of comets in the oxidant stressed cells. The extent of cytotoxicity of H 2 O 2 in the presence and the absence of leaf extracts studied in KB tumor cells by the MTT assay showed that H 2 O 2 caused a marked decrease in the viability of KB cells where as the leaf extracts effectively increased the viability of assaulted KB cells. The observed cytoprotective activity is probably due to the antioxidant properties of its constituents, mainly phenolics. Total phenolics showed higher correlation with antioxidant activity. The leaf extracts showed higher antioxidant activity than the reference compound. These results suggest that the inhibition by the leaf extracts on oxidative DNA damage could be attributed to their free radical scavenging activities and the effect evidenced in KB cells can be in part correlated to a modulation of redox-sensitive mechanisms." @default.
• W2013809085 created "2016-06-24" @default.
• W2013809085 creator A5024899609 @default.
• W2013809085 creator A5077138727 @default.
• W2013809085 date "2010-12-09" @default.
• W2013809085 modified "2023-10-14" @default.
• W2013809085 title "Modulatory effects of <i>Moringa oleifera</i> extracts against hydrogen peroxide-induced cytotoxicity and oxidative damage" @default.
• W2013809085 cites W1030653330 @default.
• W2013809085 cites W191793640 @default.
• W2013809085 cites W1929572050 @default.
• W2013809085 cites W1966551577 @default.
• W2013809085 cites W1969643746 @default.
• W2013809085 cites W1983310681 @default.
• W2013809085 cites W1987875118 @default.
• W2013809085 cites W1992363705 @default.
• W2013809085 cites W2000344483 @default.
• W2013809085 cites W2004814469 @default.
• W2013809085 cites W2013206715 @default.
• W2013809085 cites W2015631723 @default.
• W2013809085 cites W2016016056 @default.
• W2013809085 cites W2024592231 @default.
• W2013809085 cites W2038238762 @default.
• W2013809085 cites W2054526986 @default.
• W2013809085 cites W2055128095 @default.
• W2013809085 cites W2067855132 @default.
• W2013809085 cites W2092629964 @default.
• W2013809085 cites W2101956379 @default.
• W2013809085 cites W2109369458 @default.
• W2013809085 cites W2113596478 @default.
• W2013809085 cites W2119249741 @default.
• W2013809085 cites W2125446037 @default.
• W2013809085 cites W2157412052 @default.
• W2013809085 cites W2164356672 @default.
• W2013809085 cites W2168983663 @default.
• W2013809085 cites W2170959793 @default.
• W2013809085 cites W2171334157 @default.
• W2013809085 cites W2313340812 @default.
• W2013809085 cites W4376848441 @default.
• W2013809085 doi "https://doi.org/10.1177/0960327110391385" @default.
• W2013809085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21148198" @default.
• W2013809085 hasPublicationYear "2010" @default.
• W2013809085 type Work @default.
• W2013809085 sameAs 2013809085 @default.
• W2013809085 citedByCount "52" @default.
• W2013809085 countsByYear W20138090852012 @default.
• W2013809085 countsByYear W20138090852013 @default.
• W2013809085 countsByYear W20138090852014 @default.
• W2013809085 countsByYear W20138090852015 @default.
• W2013809085 countsByYear W20138090852016 @default.
• W2013809085 countsByYear W20138090852017 @default.
• W2013809085 countsByYear W20138090852018 @default.
• W2013809085 countsByYear W20138090852019 @default.
• W2013809085 countsByYear W20138090852020 @default.
• W2013809085 countsByYear W20138090852021 @default.
• W2013809085 countsByYear W20138090852022 @default.
• W2013809085 countsByYear W20138090852023 @default.
• W2013809085 crossrefType "journal-article" @default.
• W2013809085 hasAuthorship W2013809085A5024899609 @default.
• W2013809085 hasAuthorship W2013809085A5077138727 @default.
• W2013809085 hasConcept C109316439 @default.
• W2013809085 hasConcept C143425029 @default.
• W2013809085 hasConcept C153911025 @default.
• W2013809085 hasConcept C185592680 @default.
• W2013809085 hasConcept C202751555 @default.
• W2013809085 hasConcept C2775838275 @default.
• W2013809085 hasConcept C2776151105 @default.
• W2013809085 hasConcept C2776836740 @default.
• W2013809085 hasConcept C2777352226 @default.
• W2013809085 hasConcept C2777504301 @default.
• W2013809085 hasConcept C2778004101 @default.
• W2013809085 hasConcept C2778979269 @default.
• W2013809085 hasConcept C2780358455 @default.
• W2013809085 hasConcept C2780369685 @default.
• W2013809085 hasConcept C2780783641 @default.
• W2013809085 hasConcept C2780829032 @default.
• W2013809085 hasConcept C31903555 @default.
• W2013809085 hasConcept C48349386 @default.
• W2013809085 hasConcept C53227056 @default.
• W2013809085 hasConcept C533411734 @default.
• W2013809085 hasConcept C552990157 @default.
• W2013809085 hasConcept C55493867 @default.
• W2013809085 hasConcept C86803240 @default.
• W2013809085 hasConceptScore W2013809085C109316439 @default.
• W2013809085 hasConceptScore W2013809085C143425029 @default.
• W2013809085 hasConceptScore W2013809085C153911025 @default.
• W2013809085 hasConceptScore W2013809085C185592680 @default.
• W2013809085 hasConceptScore W2013809085C202751555 @default.
• W2013809085 hasConceptScore W2013809085C2775838275 @default.
• W2013809085 hasConceptScore W2013809085C2776151105 @default.
• W2013809085 hasConceptScore W2013809085C2776836740 @default.
• W2013809085 hasConceptScore W2013809085C2777352226 @default.
• W2013809085 hasConceptScore W2013809085C2777504301 @default.
• W2013809085 hasConceptScore W2013809085C2778004101 @default.
• W2013809085 hasConceptScore W2013809085C2778979269 @default.
• W2013809085 hasConceptScore W2013809085C2780358455 @default.
• W2013809085 hasConceptScore W2013809085C2780369685 @default.
• W2013809085 hasConceptScore W2013809085C2780783641 @default.
• W2013809085 hasConceptScore W2013809085C2780829032 @default.

• next