Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013810406> ?p ?o ?g. }
- W2013810406 endingPage "242" @default.
- W2013810406 startingPage "233" @default.
- W2013810406 abstract "Demyelination of the human peripheral nervous system (PNS) can be caused by diverse mechanisms including viral infection. Despite association of several viruses with the development of peripheral demyelination, animal models of the condition have been limited to disease that is either autoimmune or genetic in origin. We describe here a model of PNS demyelination based on direct injection of sciatic nerves of mice with the cardiovirus, Theiler's murine encephalomyelitis virus (TMEV). Sciatic nerves of FVB mice develop inflammatory cell infiltration following TMEV injection. Schwann cells and macrophages are infected with TMEV. Viral replication is observed initially in the sciatic nerves and subsequently the spinal cord. Sciatic nerves are demyelinated by day 5 post-inoculation (p.i.). Injecting sciatic nerves of scid mice resulted in increased levels of virus recovered from the sciatic nerve and spinal cord relative to FVB mice. Demyelination also occurred in scid mice and by 12 days p.i., hindlimbs were paralyzed. This new model of virus-induced peripheral demyelination may be used to dissect processes involved in protection of the PNS from viral insult and to study the early phases of lesion development." @default.
- W2013810406 created "2016-06-24" @default.
- W2013810406 creator A5041503539 @default.
- W2013810406 creator A5083738472 @default.
- W2013810406 date "2007-03-01" @default.
- W2013810406 modified "2023-10-18" @default.
- W2013810406 title "Injection of the sciatic nerve with TMEV: A new model for peripheral nerve demyelination" @default.
- W2013810406 cites W129740561 @default.
- W2013810406 cites W1487256485 @default.
- W2013810406 cites W1491321203 @default.
- W2013810406 cites W1532139449 @default.
- W2013810406 cites W1539249565 @default.
- W2013810406 cites W1586668407 @default.
- W2013810406 cites W1592324176 @default.
- W2013810406 cites W1632273139 @default.
- W2013810406 cites W1645663089 @default.
- W2013810406 cites W1665248256 @default.
- W2013810406 cites W1822002178 @default.
- W2013810406 cites W1837179553 @default.
- W2013810406 cites W1912497605 @default.
- W2013810406 cites W1929437198 @default.
- W2013810406 cites W1963995395 @default.
- W2013810406 cites W1966511302 @default.
- W2013810406 cites W1971474058 @default.
- W2013810406 cites W1972634437 @default.
- W2013810406 cites W1976469214 @default.
- W2013810406 cites W1979574867 @default.
- W2013810406 cites W1981428500 @default.
- W2013810406 cites W1986935118 @default.
- W2013810406 cites W1989877475 @default.
- W2013810406 cites W1998717100 @default.
- W2013810406 cites W2000031391 @default.
- W2013810406 cites W2003441522 @default.
- W2013810406 cites W2003622362 @default.
- W2013810406 cites W2009112694 @default.
- W2013810406 cites W2009295096 @default.
- W2013810406 cites W2011618157 @default.
- W2013810406 cites W2013142695 @default.
- W2013810406 cites W2013851814 @default.
- W2013810406 cites W2014396854 @default.
- W2013810406 cites W2014521377 @default.
- W2013810406 cites W2015068080 @default.
- W2013810406 cites W2017189702 @default.
- W2013810406 cites W2017885089 @default.
- W2013810406 cites W2022509550 @default.
- W2013810406 cites W2024923637 @default.
- W2013810406 cites W2026391208 @default.
- W2013810406 cites W2026423516 @default.
- W2013810406 cites W2028368557 @default.
- W2013810406 cites W2030846355 @default.
- W2013810406 cites W2032062137 @default.
- W2013810406 cites W2039315839 @default.
- W2013810406 cites W2042814927 @default.
- W2013810406 cites W2056748099 @default.
- W2013810406 cites W2059763912 @default.
- W2013810406 cites W2059930127 @default.
- W2013810406 cites W2062249785 @default.
- W2013810406 cites W2063996886 @default.
- W2013810406 cites W2065897119 @default.
- W2013810406 cites W2070983192 @default.
- W2013810406 cites W2074051982 @default.
- W2013810406 cites W2081239384 @default.
- W2013810406 cites W2082150409 @default.
- W2013810406 cites W2082655991 @default.
- W2013810406 cites W2083541317 @default.
- W2013810406 cites W2083886238 @default.
- W2013810406 cites W2089651134 @default.
- W2013810406 cites W2091078008 @default.
- W2013810406 cites W2092019188 @default.
- W2013810406 cites W2093860288 @default.
- W2013810406 cites W2095353564 @default.
- W2013810406 cites W2095890327 @default.
- W2013810406 cites W2104075272 @default.
- W2013810406 cites W2114656277 @default.
- W2013810406 cites W2115181366 @default.
- W2013810406 cites W2117340207 @default.
- W2013810406 cites W2118108549 @default.
- W2013810406 cites W2124891405 @default.
- W2013810406 cites W2129090607 @default.
- W2013810406 cites W2129724774 @default.
- W2013810406 cites W2135692686 @default.
- W2013810406 cites W2138911503 @default.
- W2013810406 cites W2141939380 @default.
- W2013810406 cites W2145279894 @default.
- W2013810406 cites W2147079101 @default.
- W2013810406 cites W2150491428 @default.
- W2013810406 cites W2156226459 @default.
- W2013810406 cites W2160690239 @default.
- W2013810406 cites W2160952736 @default.
- W2013810406 cites W2161530562 @default.
- W2013810406 cites W2167102696 @default.
- W2013810406 cites W2171017732 @default.
- W2013810406 cites W2299597421 @default.
- W2013810406 cites W2338823978 @default.
- W2013810406 cites W2400060567 @default.
- W2013810406 cites W2414135247 @default.
- W2013810406 cites W2414141065 @default.
- W2013810406 cites W2430228701 @default.