FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013813772> ?p ?o ?g. }

• W2013813772 endingPage "4461" @default.
• W2013813772 startingPage "4455" @default.
• W2013813772 abstract "Prostate specific membrane antigen (PSMA) is a 110 kDa type II transmembrane protein that is expressed exclusively by prostate tumor cells and as such is a clear cellular target in the development of a new method for fast and reliable diagnosis of prostate cancer. PSMA is highly homologous to the neuropeptidase NAALADase, and it has been shown that inhibitors of NAALADase also strongly bind to PSMA. In an effort to better understand the structural basis of the inhibitory activity of more than 60NAALADase inhibitors synthesized and tested by our group, we used Monte Carlo calculations employing the Merck Molecular Force Field to explore the conformational space available to a set of PSMA inhibitors. Conformational analysis indicated that the lower the number of unique conformations accessible by an inhibitor, the greater the biological activity displayed by the compound against LnCAP cells. This suggests that the difference in activity is largely entropy based. The key conformations associated with high activity are used to develop a simple pharmacophore model that led to the design of new, conformationally restricted analogues with potentially high activity in rational drug design." @default.
• W2013813772 created "2016-06-24" @default.
• W2013813772 creator A5006603399 @default.
• W2013813772 creator A5021412051 @default.
• W2013813772 creator A5029114040 @default.
• W2013813772 creator A5036175953 @default.
• W2013813772 creator A5091265699 @default.
• W2013813772 date "2003-10-01" @default.
• W2013813772 modified "2023-09-26" @default.
• W2013813772 title "Conformational and SAR analysis of NAALADase and PSMA inhibitors" @default.
• W2013813772 cites W1964608935 @default.
• W2013813772 cites W1971572370 @default.
• W2013813772 cites W1986755460 @default.
• W2013813772 cites W1989792962 @default.
• W2013813772 cites W1990559915 @default.
• W2013813772 cites W1992868992 @default.
• W2013813772 cites W1994303809 @default.
• W2013813772 cites W1996301461 @default.
• W2013813772 cites W2017234411 @default.
• W2013813772 cites W2037319728 @default.
• W2013813772 cites W2063649715 @default.
• W2013813772 cites W2080048885 @default.
• W2013813772 cites W2086130715 @default.
• W2013813772 cites W2121853844 @default.
• W2013813772 cites W2147421370 @default.
• W2013813772 cites W2148150393 @default.
• W2013813772 cites W2166114438 @default.
• W2013813772 cites W4235618704 @default.
• W2013813772 doi "https://doi.org/10.1016/s0968-0896(03)00427-9" @default.
• W2013813772 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/13129582" @default.
• W2013813772 hasPublicationYear "2003" @default.
• W2013813772 type Work @default.
• W2013813772 sameAs 2013813772 @default.
• W2013813772 citedByCount "17" @default.
• W2013813772 countsByYear W20138137722012 @default.
• W2013813772 countsByYear W20138137722014 @default.
• W2013813772 countsByYear W20138137722015 @default.
• W2013813772 countsByYear W20138137722016 @default.
• W2013813772 countsByYear W20138137722019 @default.
• W2013813772 countsByYear W20138137722020 @default.
• W2013813772 crossrefType "journal-article" @default.
• W2013813772 hasAuthorship W2013813772A5006603399 @default.
• W2013813772 hasAuthorship W2013813772A5021412051 @default.
• W2013813772 hasAuthorship W2013813772A5029114040 @default.
• W2013813772 hasAuthorship W2013813772A5036175953 @default.
• W2013813772 hasAuthorship W2013813772A5091265699 @default.
• W2013813772 hasConcept C116073593 @default.
• W2013813772 hasConcept C121608353 @default.
• W2013813772 hasConcept C126322002 @default.
• W2013813772 hasConcept C170493617 @default.
• W2013813772 hasConcept C171250308 @default.
• W2013813772 hasConcept C185592680 @default.
• W2013813772 hasConcept C192562407 @default.
• W2013813772 hasConcept C202751555 @default.
• W2013813772 hasConcept C20417620 @default.
• W2013813772 hasConcept C24530287 @default.
• W2013813772 hasConcept C2779281246 @default.
• W2013813772 hasConcept C2779564779 @default.
• W2013813772 hasConcept C2779723316 @default.
• W2013813772 hasConcept C2780192828 @default.
• W2013813772 hasConcept C53105671 @default.
• W2013813772 hasConcept C55493867 @default.
• W2013813772 hasConcept C56173144 @default.
• W2013813772 hasConcept C70721500 @default.
• W2013813772 hasConcept C71240020 @default.
• W2013813772 hasConcept C71924100 @default.
• W2013813772 hasConcept C86803240 @default.
• W2013813772 hasConceptScore W2013813772C116073593 @default.
• W2013813772 hasConceptScore W2013813772C121608353 @default.
• W2013813772 hasConceptScore W2013813772C126322002 @default.
• W2013813772 hasConceptScore W2013813772C170493617 @default.
• W2013813772 hasConceptScore W2013813772C171250308 @default.
• W2013813772 hasConceptScore W2013813772C185592680 @default.
• W2013813772 hasConceptScore W2013813772C192562407 @default.
• W2013813772 hasConceptScore W2013813772C202751555 @default.
• W2013813772 hasConceptScore W2013813772C20417620 @default.
• W2013813772 hasConceptScore W2013813772C24530287 @default.
• W2013813772 hasConceptScore W2013813772C2779281246 @default.
• W2013813772 hasConceptScore W2013813772C2779564779 @default.
• W2013813772 hasConceptScore W2013813772C2779723316 @default.
• W2013813772 hasConceptScore W2013813772C2780192828 @default.
• W2013813772 hasConceptScore W2013813772C53105671 @default.
• W2013813772 hasConceptScore W2013813772C55493867 @default.
• W2013813772 hasConceptScore W2013813772C56173144 @default.
• W2013813772 hasConceptScore W2013813772C70721500 @default.
• W2013813772 hasConceptScore W2013813772C71240020 @default.
• W2013813772 hasConceptScore W2013813772C71924100 @default.
• W2013813772 hasConceptScore W2013813772C86803240 @default.
• W2013813772 hasIssue "20" @default.
• W2013813772 hasLocation W20138137721 @default.
• W2013813772 hasLocation W20138137722 @default.
• W2013813772 hasOpenAccess W2013813772 @default.
• W2013813772 hasPrimaryLocation W20138137721 @default.
• W2013813772 hasRelatedWork W2013813772 @default.
• W2013813772 hasRelatedWork W2059956107 @default.
• W2013813772 hasRelatedWork W2078109202 @default.
• W2013813772 hasRelatedWork W2082973577 @default.
• W2013813772 hasRelatedWork W2092975759 @default.

• next