FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013824432> ?p ?o ?g. }

• W2013824432 endingPage "974" @default.
• W2013824432 startingPage "963" @default.
• W2013824432 abstract "Rran-dependent nuclear transport requires a nuclear pool of RanGTP both for the assembly of export complexes and the disassembly of import complexes. Accordingly, in order for these processes to proceed, Ran-dependent nuclear import and export assays in vitro require the addition of GTP to produce RanGTP. Notably, no ATP requirement can be detected for these transport processes in vitro. But in vivo, when cells are depleted of ATP by the addition of sodium azide and 2-deoxyglucose to block ATP production by oxidative phosphorylation and glycolysis, respectively, Ran-dependent nuclear import and export are rapidly inhibited. This raised the question of whether there is an ATP requirement for these nuclear transport pathways in an intact cell that has remained undetected in vitro. Here we report that the free (but not total) GTP concentration rapidly drops to an undetectable level upon ATP depletion as does the availability of RanGTP. Our conclusion is that the inhibition of Ran-dependent nuclear transport observed upon ATP depletion in vivo results from a shortage of RanGTP rather than the inhibition of some ATP-dependent process." @default.
• W2013824432 created "2016-06-24" @default.
• W2013824432 creator A5058616214 @default.
• W2013824432 creator A5058650905 @default.
• W2013824432 creator A5078229043 @default.
• W2013824432 date "2002-06-10" @default.
• W2013824432 modified "2023-10-10" @default.
• W2013824432 title "The mechanism of inhibition of Ran-dependent nuclear transport by cellular ATP depletion" @default.
• W2013824432 cites W1503329918 @default.
• W2013824432 cites W1533325686 @default.
• W2013824432 cites W1544256708 @default.
• W2013824432 cites W1594127521 @default.
• W2013824432 cites W1596268728 @default.
• W2013824432 cites W1768329327 @default.
• W2013824432 cites W1902070349 @default.
• W2013824432 cites W1963705823 @default.
• W2013824432 cites W1964667809 @default.
• W2013824432 cites W1973052124 @default.
• W2013824432 cites W1977805236 @default.
• W2013824432 cites W1981068092 @default.
• W2013824432 cites W1985706424 @default.
• W2013824432 cites W1987945169 @default.
• W2013824432 cites W1991018390 @default.
• W2013824432 cites W1995247882 @default.
• W2013824432 cites W1998849903 @default.
• W2013824432 cites W2004004385 @default.
• W2013824432 cites W2008922773 @default.
• W2013824432 cites W2009829119 @default.
• W2013824432 cites W2013127041 @default.
• W2013824432 cites W2015590530 @default.
• W2013824432 cites W2031766817 @default.
• W2013824432 cites W2036429346 @default.
• W2013824432 cites W2044788514 @default.
• W2013824432 cites W2049807410 @default.
• W2013824432 cites W2050230359 @default.
• W2013824432 cites W2057968668 @default.
• W2013824432 cites W2058041522 @default.
• W2013824432 cites W2060930539 @default.
• W2013824432 cites W2073526608 @default.
• W2013824432 cites W2107427363 @default.
• W2013824432 cites W2113459103 @default.
• W2013824432 cites W2123110333 @default.
• W2013824432 cites W2125824495 @default.
• W2013824432 cites W2132320427 @default.
• W2013824432 cites W2132672808 @default.
• W2013824432 cites W2133201628 @default.
• W2013824432 cites W2143432207 @default.
• W2013824432 cites W2157711349 @default.
• W2013824432 cites W2165562991 @default.
• W2013824432 cites W2172274948 @default.
• W2013824432 cites W2172298521 @default.
• W2013824432 cites W2285492390 @default.
• W2013824432 cites W2414492905 @default.
• W2013824432 cites W2427117587 @default.
• W2013824432 cites W2804367574 @default.
• W2013824432 cites W2034865288 @default.
• W2013824432 doi "https://doi.org/10.1083/jcb.200111077" @default.
• W2013824432 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2174045" @default.
• W2013824432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12058015" @default.
• W2013824432 hasPublicationYear "2002" @default.
• W2013824432 type Work @default.
• W2013824432 sameAs 2013824432 @default.
• W2013824432 citedByCount "117" @default.
• W2013824432 countsByYear W20138244322012 @default.
• W2013824432 countsByYear W20138244322013 @default.
• W2013824432 countsByYear W20138244322014 @default.
• W2013824432 countsByYear W20138244322015 @default.
• W2013824432 countsByYear W20138244322016 @default.
• W2013824432 countsByYear W20138244322017 @default.
• W2013824432 countsByYear W20138244322018 @default.
• W2013824432 countsByYear W20138244322019 @default.
• W2013824432 countsByYear W20138244322020 @default.
• W2013824432 countsByYear W20138244322021 @default.
• W2013824432 countsByYear W20138244322022 @default.
• W2013824432 countsByYear W20138244322023 @default.
• W2013824432 crossrefType "journal-article" @default.
• W2013824432 hasAuthorship W2013824432A5058616214 @default.
• W2013824432 hasAuthorship W2013824432A5058650905 @default.
• W2013824432 hasAuthorship W2013824432A5078229043 @default.
• W2013824432 hasBestOaLocation W20138244321 @default.
• W2013824432 hasConcept C118716 @default.
• W2013824432 hasConcept C160704184 @default.
• W2013824432 hasConcept C181199279 @default.
• W2013824432 hasConcept C20251656 @default.
• W2013824432 hasConcept C2779564974 @default.
• W2013824432 hasConcept C2780114586 @default.
• W2013824432 hasConcept C2780723820 @default.
• W2013824432 hasConcept C54757728 @default.
• W2013824432 hasConcept C55493867 @default.
• W2013824432 hasConcept C57600042 @default.
• W2013824432 hasConcept C59157529 @default.
• W2013824432 hasConcept C62231903 @default.
• W2013824432 hasConcept C86803240 @default.
• W2013824432 hasConcept C95444343 @default.
• W2013824432 hasConceptScore W2013824432C118716 @default.
• W2013824432 hasConceptScore W2013824432C160704184 @default.
• W2013824432 hasConceptScore W2013824432C181199279 @default.
• W2013824432 hasConceptScore W2013824432C20251656 @default.

• next