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• W2013825138 abstract "Posttransplant diabetes mellitus (PTDM) is an important complication in a tacrolimus (TAC)-based immunosuppressive regimen. The present study investigated the incidence, clinical risk factors, TAC pharmacokinetics (PK), and genomic polymorphisms related to TAC-PK or diabetes mellitus (DM) under the TAC-based immunosuppressive protocol. Seventy-one nondiabetic renal allograft recipients transplanted from February 1998 to March 2004 were studied. Patients with over 6.5 mg/dL of hemoglobin A1c on sequential blood samples or requiring insulin or oral antidiabetic agents around 6 months after transplantation were diagnosed as having PTDM. Six months after transplantation, 10 recipients (14.1%) developed PTDM. The positive risk factors were age ( P = .003) and body mass index ( P = .035). There were no significant differences in gender distribution, pretransplant dialysis period, dialysis modality, acute rejection rate, total steroid doses, TAC-PK, or its related genomic polymorphisms between the two groups. In the DM-related polymorphisms, the frequency of PTDM was significant higher in patients with the VDR Taq I tt or Tt genotype than in those with the TT genotype ( P = .013). After a multivariate analysis, age over 50 years ( P = .007, odds ratio 8.92) and the presence of VDR Taq I t allele ( P = .043, odds ratio 6.71) were correlated with the development of PTDM. The incidence of PTDM in our series was 14.1%. Age over 50 years was a risk factor. The presence of VDR Taq I t allele might be a risk for PTDM. An association between TAC-PK and development of PTDM was not observed." @default.
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• W2013825138 date "2005-05-01" @default.
• W2013825138 modified "2023-09-23" @default.
• W2013825138 title "Incidence and Risk Factors of Clinical Characteristics, Tacrolimus Pharmacokinetics, and Related Genomic Polymorphisms for Posttransplant Diabetes Mellitus in the Early Stage of Renal Transplant Recipients" @default.
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• W2013825138 doi "https://doi.org/10.1016/j.transproceed.2005.02.086" @default.
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