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- W2013832480 abstract "Abstract To determine the relationships between glycosaminoglycan (GAG) synthesis and type-specific collagen synthesis, we have investigated mouse limbs cultured in the presence of antiglutamine DON (6-diazo-5-oxo- l -norleucine). When compared to control limbs, ultrastructural examination of the DON-treated limbs shows that newly formed cartilage lacks matrix granules and the collagen fibrils have an altered morphology. Using [35S]sulfate as a precursor, we have found that DON (5 μg/ml) suppresses chondroitin sulfate synthesis to less than 15% of the control level. We have also examined the collagen synthesized in equivalent limbs labeled with [3H]proline. The α-chain patterns from CM-cellulose chromatography were very similar for control and experimental limbs (α1:α2 ∼ 7), suggesting that both (α1)3- and (α1)2α2-type molecules were being produced. The (α1)3 molecules in both cases were identified as type II collagen by fractional salt separation and cyanogen bromide peptide mapping on CM-cellulose columns. We conclude that (1) the synthesis of type II collagen can be dissociated from the production of GAG, and (2) environmental influences can be involved in controlling the fibrillogenesis of collagen." @default.
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- W2013832480 date "1979-04-01" @default.
- W2013832480 modified "2023-09-23" @default.
- W2013832480 title "In vitro cartilage formation: Effects of 6-diazo-5-oxo-l-norleucine (DON) on glycosaminoglycan and collagen synthesis" @default.
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- W2013832480 doi "https://doi.org/10.1016/0012-1606(79)90309-9" @default.
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