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- W2013837049 abstract "1 The uptake of 5-hydroxytryptamine (5-HT) by rat blood platelets in citrated plasma was linear for at most 10 s and was substantially complete within 3 minutes. 2 Adenosine 5'-diphosphate (ADP) was a potent inhibitor of 5-HT uptake (Ki=0.38 muM) and kinetic analysis revealed that the inhibition was not competitive. 3 Inhibition of 5-HT uptake by ADP was abolished in the presence of prostaglandin E1 and 2-n-amylthio-AMP, which also inhibit the stimulant actions of ADP on blood platelets. 4 It is concluded that ADP could inhibit 5-HT uptake by changing the Na+/K+ distribution across the cell membrane, and the biological significance of this is discussed." @default.
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- W2013837049 date "1976-04-01" @default.
- W2013837049 modified "2023-09-24" @default.
- W2013837049 title "UPTAKE OF 5-HYDROXYTRYPTAMINE BY RAT BLOOD PLATELETS AND ITS INHIBITION BY ADENOSINE 5‘-DIPHOSPHATE" @default.
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- W2013837049 doi "https://doi.org/10.1111/j.1476-5381.1976.tb07452.x" @default.
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