Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013837108> ?p ?o ?g. }
- W2013837108 endingPage "1380" @default.
- W2013837108 startingPage "1371" @default.
- W2013837108 abstract "Alzheimer disease (AD) is a major health problem in the United States, affecting one in eight Americans over the age of 65. The number of elderly suffering from AD is expected to continue to increase over the next decade, as the average age of the U.S. population increases. The risk factors for and etiology of AD are not well understood; however, recent studies suggest that exposure to oxidative stress may be a contributing factor. Here, microarray gene expression signatures were compared in AD-patient-derived fibroblasts and normal fibroblasts exposed to hydrogen peroxide or menadione (to simulate conditions of oxidative stress). Using the 23K Illumina cDNA microarray to screen expression of >14,000 human genes, we identified a total of 1017 genes that are chronically up- or downregulated in AD fibroblasts, 215 of which were also differentially expressed in normal human fibroblasts within 12h after exposure to hydrogen peroxide or menadione. Pathway analysis of these 215 genes and their associated pathways revealed cellular functions that may be critically dysregulated by oxidative stress and play a critical role in the etiology and/or pathology of AD. We then examined the AD fibroblasts for the presence of oxidative DNA damage and found increased accumulation of 8-oxo-guanine. These results indicate the possible role of oxidative stress in the gene expression profile seen in AD." @default.
- W2013837108 created "2016-06-24" @default.
- W2013837108 creator A5008850808 @default.
- W2013837108 creator A5017116006 @default.
- W2013837108 creator A5017796398 @default.
- W2013837108 creator A5038249001 @default.
- W2013837108 creator A5052081713 @default.
- W2013837108 creator A5069694896 @default.
- W2013837108 creator A5069851925 @default.
- W2013837108 creator A5079904550 @default.
- W2013837108 creator A5089917586 @default.
- W2013837108 date "2012-09-01" @default.
- W2013837108 modified "2023-10-14" @default.
- W2013837108 title "Sporadic Alzheimer disease fibroblasts display an oxidative stress phenotype" @default.
- W2013837108 cites W1558580604 @default.
- W2013837108 cites W1651705209 @default.
- W2013837108 cites W1661470104 @default.
- W2013837108 cites W1848907877 @default.
- W2013837108 cites W1896970469 @default.
- W2013837108 cites W1970028828 @default.
- W2013837108 cites W1970965314 @default.
- W2013837108 cites W1972659631 @default.
- W2013837108 cites W1973216353 @default.
- W2013837108 cites W1973800714 @default.
- W2013837108 cites W1976807955 @default.
- W2013837108 cites W1977813572 @default.
- W2013837108 cites W1977896329 @default.
- W2013837108 cites W1984866675 @default.
- W2013837108 cites W1985208032 @default.
- W2013837108 cites W1985816664 @default.
- W2013837108 cites W1994619720 @default.
- W2013837108 cites W1996669272 @default.
- W2013837108 cites W1999790244 @default.
- W2013837108 cites W2001318724 @default.
- W2013837108 cites W2005912218 @default.
- W2013837108 cites W2006527080 @default.
- W2013837108 cites W2007614811 @default.
- W2013837108 cites W2008162897 @default.
- W2013837108 cites W2008743975 @default.
- W2013837108 cites W2009868142 @default.
- W2013837108 cites W2010009765 @default.
- W2013837108 cites W2010533973 @default.
- W2013837108 cites W2010571809 @default.
- W2013837108 cites W2013876822 @default.
- W2013837108 cites W2015471410 @default.
- W2013837108 cites W2018961056 @default.
- W2013837108 cites W2019297242 @default.
- W2013837108 cites W2019914155 @default.
- W2013837108 cites W2021339001 @default.
- W2013837108 cites W2024943443 @default.
- W2013837108 cites W2031762170 @default.
- W2013837108 cites W2032350023 @default.
- W2013837108 cites W2039820498 @default.
- W2013837108 cites W2040414606 @default.
- W2013837108 cites W2041685210 @default.
- W2013837108 cites W2047041100 @default.
- W2013837108 cites W2049972682 @default.
- W2013837108 cites W2056384210 @default.
- W2013837108 cites W2056585943 @default.
- W2013837108 cites W2056648984 @default.
- W2013837108 cites W2058707564 @default.
- W2013837108 cites W2059831889 @default.
- W2013837108 cites W2061378782 @default.
- W2013837108 cites W2062604048 @default.
- W2013837108 cites W2064355322 @default.
- W2013837108 cites W2065013480 @default.
- W2013837108 cites W2067087475 @default.
- W2013837108 cites W2067306804 @default.
- W2013837108 cites W2068943282 @default.
- W2013837108 cites W2071288242 @default.
- W2013837108 cites W2072092279 @default.
- W2013837108 cites W2076961377 @default.
- W2013837108 cites W2081219796 @default.
- W2013837108 cites W2082294005 @default.
- W2013837108 cites W2084727872 @default.
- W2013837108 cites W2084979786 @default.
- W2013837108 cites W2085043108 @default.
- W2013837108 cites W2087367816 @default.
- W2013837108 cites W2088856765 @default.
- W2013837108 cites W2089038479 @default.
- W2013837108 cites W2094485553 @default.
- W2013837108 cites W2102060609 @default.
- W2013837108 cites W2102074241 @default.
- W2013837108 cites W2105236625 @default.
- W2013837108 cites W2112451788 @default.
- W2013837108 cites W2114729479 @default.
- W2013837108 cites W2114825009 @default.
- W2013837108 cites W2122230892 @default.
- W2013837108 cites W2123106337 @default.
- W2013837108 cites W2124624490 @default.
- W2013837108 cites W2124634545 @default.
- W2013837108 cites W2124928315 @default.
- W2013837108 cites W2130410032 @default.
- W2013837108 cites W2132201451 @default.
- W2013837108 cites W2134802476 @default.
- W2013837108 cites W2136743671 @default.
- W2013837108 cites W2149937665 @default.
- W2013837108 cites W2151330369 @default.