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• W2013837909 abstract "Radiation therapy (RT) plays a critical role in the local tumor control of benign and low-grade central nervous system tumors in children but is not without the risk of long-term treatment-related sequelae. Proton therapy (PRT) is an advanced RT modality with a unique dose-deposition pattern that allows for treatment of a target volume with reduced scatter dose delivered to normal tissues compared with conventional photon RT and is now increasingly utilized in children with the hope of mitigating radiation-induced late effects. This article reviews the current literature evaluating the use of PRT in benign and low-grade pediatric central nervous system tumors such as low-grade glioma, craniopharyngioma, and ependymoma. Multiple dosimetric studies support the use of PRT by demonstrating the ability of PRT to better spare critical structures important for cognitive development, endocrine function, and hearing preservation and to reduce the total body dose associated with second malignancy risk. Early clinical data demonstrate that PRT is well tolerated with rates of local tumor control comparable to conventional photon RT series, and long-term clinical data are awaited." @default.
• W2013837909 created "2016-06-24" @default.
• W2013837909 creator A5014884181 @default.
• W2013837909 creator A5080153222 @default.
• W2013837909 date "2014-11-01" @default.
• W2013837909 modified "2023-09-23" @default.
• W2013837909 title "The Use of Proton Therapy in the Treatment of Benign or Low-Grade Pediatric Brain Tumors" @default.
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• W2013837909 doi "https://doi.org/10.1097/ppo.0000000000000079" @default.
• W2013837909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25415686" @default.
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