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- W2013840898 abstract "Background: Current models for assessing breast cancer risk are complex and do not include breast density, a strong risk factor for breast cancer that is routinely reported with mammography. Objective: To develop and validate an easy-to-use breast cancer risk prediction model that includes breast density. Design: Empirical model based on Surveillance, Epidemiology, and End Results incidence, and relative hazards from a prospective cohort. Setting: Screening mammography sites participating in the Breast Cancer Surveillance Consortium. Patients: 1 095 484 women undergoing mammography who had no previous diagnosis of breast cancer. Measurements: Self-reported age, race or ethnicity, family history of breast cancer, and history of breast biopsy. Community radiologists rated breast density by using 4 Breast Imaging Reporting and Data System categories. Results: During 5.3 years of follow-up, invasive breast cancer was diagnosed in 14 766 women. The breast density model was well calibrated overall (expected–observed ratio, 1.03 [95% CI, 0.99 to 1.06]) and in racial and ethnic subgroups. It had modest discriminatory accuracy (concordance index, 0.66 [CI, 0.65 to 0.67]). Women with low-density mammograms had 5-year risks less than 1.67% unless they had a family history of breast cancer and were older than age 65 years. Limitation: The model has only modest ability to discriminate between women who will develop breast cancer and those who will not. Conclusion: A breast cancer prediction model that incorporates routinely reported measures of breast density can estimate 5-year risk for invasive breast cancer. Its accuracy needs to be further evaluated in independent populations before it can be recommended for clinical use." @default.
- W2013840898 created "2016-06-24" @default.
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- W2013840898 date "2008-03-04" @default.
- W2013840898 modified "2023-09-28" @default.
- W2013840898 title "Using Clinical Factors and Mammographic Breast Density to Estimate Breast Cancer Risk: Development and Validation of a New Predictive Model" @default.
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- W2013840898 doi "https://doi.org/10.7326/0003-4819-148-5-200803040-00004" @default.
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