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- W2013842503 abstract "Abstract The effect of the anti-hypertensive drug, St 155, on the active reflex vasodilatation induced by intravenous administration of adrenaline, nonadrenaline and veratrine has been studied in autoperfused and saline perfused hindquarters of anaesthetised cats. St 155 markedly depressed the active reflex vasodilatation in the autoperfused preparations and completely abolished the reflex in saline perfused preparations. The reduction of this reflex can only be partly explained by the ability of St 155 to abolish the baroreceptor reflex and it cannot be entirely due to the loss of sympathetic tone in the vasculature of the perfused area. Therefore, it is unlikely that the hypotensive action of St 155 is due to increased dilator reflexes. However, the disappearance of this reflex may provide explanation for the absence of postural hypotension reported during clinical trial. The perfusion pressure of the hindquarters was reduced only by intravenous administration of St 155, but not when it was perfused through the hindlimbs. The results add further support to the suggestion that St 155 acts via a central mechanism." @default.
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- W2013842503 date "1969-10-01" @default.
- W2013842503 modified "2023-09-25" @default.
- W2013842503 title "The effect of St 155 on the active reflex vasodilatation induced by adrenaline, noradrenaline and veratrine" @default.
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- W2013842503 doi "https://doi.org/10.1016/0014-2999(69)90127-7" @default.
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