Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013847385> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2013847385 endingPage "192" @default.
- W2013847385 startingPage "188" @default.
- W2013847385 abstract "ABSTRACT: The effects of treatment with 0.2 mg/kg of indomethacin on the cerebral blood flow and cerebral oxygen consumption of hypotensive, unanesthetized, newborn pigs were investigated. Hypotension was induced by hemorrhage (30 ml/kg) which reduced mean arterial pressure from 60 to 34 mm Hg. The decline in cerebral vascular resistance that occurred with hemorrhage allowed blood flow to all brain regions and cerebral oxygen consumption to continue unchanged. Treatment with 0.2 mg of indomethacin decreased plasma 6-keto-prostaglandin F1α markedly and caused a modest increase in cerebral vascular resistance from 0.75 ± 0.07 to 0.85 ± 0.02 mm Hg·100g·min/ml at 40 min posttreatment. As a result, blood flow throughout the brain fell about 20%. Similarly, cerebral oxygen consumption declined from 2.88 ± 0.13 to 2.03 ± 0.21 O2/100 g·min following treatment of hypotensive piglets with 0.2 mg/kg of indomethacin. However, all piglets were conscious 40 min after treatment. We conclude that, although 0.2 mg/kg of indomethacin affects cerebral hemodynamics of hypotensive piglets, the effects are very modest in comparison to large increases in cerebral vascular resistance, decreases in cerebral blood flow and oxygen consumption, and coma that follow treatment of hypotensive piglets with 5 mg/kg of indomethacin." @default.
- W2013847385 created "2016-06-24" @default.
- W2013847385 creator A5010883315 @default.
- W2013847385 creator A5040836134 @default.
- W2013847385 creator A5089052390 @default.
- W2013847385 date "1987-02-01" @default.
- W2013847385 modified "2023-09-26" @default.
- W2013847385 title "Effect of Therapeutic Dose of Indomethacin on the Cerebral Circulation of Newborn Pigs" @default.
- W2013847385 doi "https://doi.org/10.1203/00006450-198702000-00015" @default.
- W2013847385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3822599" @default.
- W2013847385 hasPublicationYear "1987" @default.
- W2013847385 type Work @default.
- W2013847385 sameAs 2013847385 @default.
- W2013847385 citedByCount "29" @default.
- W2013847385 countsByYear W20138473852013 @default.
- W2013847385 countsByYear W20138473852018 @default.
- W2013847385 crossrefType "journal-article" @default.
- W2013847385 hasAuthorship W2013847385A5010883315 @default.
- W2013847385 hasAuthorship W2013847385A5040836134 @default.
- W2013847385 hasAuthorship W2013847385A5089052390 @default.
- W2013847385 hasBestOaLocation W20138473851 @default.
- W2013847385 hasConcept C119671327 @default.
- W2013847385 hasConcept C126322002 @default.
- W2013847385 hasConcept C157767197 @default.
- W2013847385 hasConcept C178790620 @default.
- W2013847385 hasConcept C178853913 @default.
- W2013847385 hasConcept C185592680 @default.
- W2013847385 hasConcept C42219234 @default.
- W2013847385 hasConcept C540031477 @default.
- W2013847385 hasConcept C58245268 @default.
- W2013847385 hasConcept C71924100 @default.
- W2013847385 hasConcept C84393581 @default.
- W2013847385 hasConceptScore W2013847385C119671327 @default.
- W2013847385 hasConceptScore W2013847385C126322002 @default.
- W2013847385 hasConceptScore W2013847385C157767197 @default.
- W2013847385 hasConceptScore W2013847385C178790620 @default.
- W2013847385 hasConceptScore W2013847385C178853913 @default.
- W2013847385 hasConceptScore W2013847385C185592680 @default.
- W2013847385 hasConceptScore W2013847385C42219234 @default.
- W2013847385 hasConceptScore W2013847385C540031477 @default.
- W2013847385 hasConceptScore W2013847385C58245268 @default.
- W2013847385 hasConceptScore W2013847385C71924100 @default.
- W2013847385 hasConceptScore W2013847385C84393581 @default.
- W2013847385 hasIssue "2" @default.
- W2013847385 hasLocation W20138473851 @default.
- W2013847385 hasLocation W20138473852 @default.
- W2013847385 hasOpenAccess W2013847385 @default.
- W2013847385 hasPrimaryLocation W20138473851 @default.
- W2013847385 hasRelatedWork W1991251792 @default.
- W2013847385 hasRelatedWork W2075257046 @default.
- W2013847385 hasRelatedWork W2112433777 @default.
- W2013847385 hasRelatedWork W2134878907 @default.
- W2013847385 hasRelatedWork W2144927034 @default.
- W2013847385 hasRelatedWork W2159987582 @default.
- W2013847385 hasRelatedWork W2322120226 @default.
- W2013847385 hasRelatedWork W2413296698 @default.
- W2013847385 hasRelatedWork W2414605864 @default.
- W2013847385 hasRelatedWork W4282933897 @default.
- W2013847385 hasVolume "21" @default.
- W2013847385 isParatext "false" @default.
- W2013847385 isRetracted "false" @default.
- W2013847385 magId "2013847385" @default.
- W2013847385 workType "article" @default.