Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013851403> ?p ?o ?g. }
- W2013851403 endingPage "9" @default.
- W2013851403 startingPage "1" @default.
- W2013851403 abstract "Monosodium glutamate (MSG) is a flavor enhancer, largely used in the food industry and it was reported to have excitotoxic effects. Higher amounts of MSG consumption have been related with increased risk of many diseases, including Chinese restaurant syndrome and metabolic syndromes in human. This study investigated the protective effects of N-acetylcysteine (NAC) on MSG-induced cytotoxicity in C6 astrocytic cells. MSG (20 mM)-induced reactive oxygen species (ROS) generation and apoptotic cell death were significantly attenuated by NAC (500 μM) pretreatment. NAC effectively inhibited the MSG-induced mitochondrial membrane potential (MMP) loss and intracellular reduced glutathione (GSH) depletion. In addition, NAC significantly attenuated MSG-induced endoplasmic reticulum (ER) stress markers, such as XBP1 splicing and CHOP, PERK, and GRP78 up-regulation. Furthermore, NAC prevented the changes of MSG-induced Bcl-2 expression level. These results suggest that NAC can protect C6 astrocytic cells against MSG-induced oxidative stress, mitochondrial dysfunction, and ER stress." @default.
- W2013851403 created "2016-06-24" @default.
- W2013851403 creator A5005620849 @default.
- W2013851403 creator A5023775442 @default.
- W2013851403 creator A5044467468 @default.
- W2013851403 creator A5048160692 @default.
- W2013851403 creator A5056921442 @default.
- W2013851403 creator A5069925656 @default.
- W2013851403 creator A5078416571 @default.
- W2013851403 creator A5089704428 @default.
- W2013851403 date "2014-05-01" @default.
- W2013851403 modified "2023-10-18" @default.
- W2013851403 title "Protective effects of N-acetylcysteine against monosodium glutamate-induced astrocytic cell death" @default.
- W2013851403 cites W1512743604 @default.
- W2013851403 cites W1529033378 @default.
- W2013851403 cites W1540520344 @default.
- W2013851403 cites W1947475203 @default.
- W2013851403 cites W1955472763 @default.
- W2013851403 cites W1961367527 @default.
- W2013851403 cites W1970090817 @default.
- W2013851403 cites W1971335269 @default.
- W2013851403 cites W1978171275 @default.
- W2013851403 cites W1978895733 @default.
- W2013851403 cites W1988564949 @default.
- W2013851403 cites W1989173007 @default.
- W2013851403 cites W1990388256 @default.
- W2013851403 cites W1995317658 @default.
- W2013851403 cites W1999142774 @default.
- W2013851403 cites W2003906356 @default.
- W2013851403 cites W2010752563 @default.
- W2013851403 cites W2016293448 @default.
- W2013851403 cites W2019347164 @default.
- W2013851403 cites W2020067472 @default.
- W2013851403 cites W2021487557 @default.
- W2013851403 cites W2029034757 @default.
- W2013851403 cites W2032444015 @default.
- W2013851403 cites W2039574372 @default.
- W2013851403 cites W2053513692 @default.
- W2013851403 cites W2060719045 @default.
- W2013851403 cites W2064663397 @default.
- W2013851403 cites W2064951237 @default.
- W2013851403 cites W2068770106 @default.
- W2013851403 cites W2090331565 @default.
- W2013851403 cites W2104706005 @default.
- W2013851403 cites W2107601804 @default.
- W2013851403 cites W2115668297 @default.
- W2013851403 cites W2117863887 @default.
- W2013851403 cites W2123957943 @default.
- W2013851403 cites W2128598497 @default.
- W2013851403 cites W2148950374 @default.
- W2013851403 cites W2159795375 @default.
- W2013851403 cites W2174925893 @default.
- W2013851403 cites W250102117 @default.
- W2013851403 cites W2588932223 @default.
- W2013851403 doi "https://doi.org/10.1016/j.fct.2014.02.015" @default.
- W2013851403 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24556569" @default.
- W2013851403 hasPublicationYear "2014" @default.
- W2013851403 type Work @default.
- W2013851403 sameAs 2013851403 @default.
- W2013851403 citedByCount "20" @default.
- W2013851403 countsByYear W20138514032014 @default.
- W2013851403 countsByYear W20138514032015 @default.
- W2013851403 countsByYear W20138514032016 @default.
- W2013851403 countsByYear W20138514032017 @default.
- W2013851403 countsByYear W20138514032018 @default.
- W2013851403 countsByYear W20138514032019 @default.
- W2013851403 countsByYear W20138514032020 @default.
- W2013851403 countsByYear W20138514032021 @default.
- W2013851403 countsByYear W20138514032022 @default.
- W2013851403 countsByYear W20138514032023 @default.
- W2013851403 crossrefType "journal-article" @default.
- W2013851403 hasAuthorship W2013851403A5005620849 @default.
- W2013851403 hasAuthorship W2013851403A5023775442 @default.
- W2013851403 hasAuthorship W2013851403A5044467468 @default.
- W2013851403 hasAuthorship W2013851403A5048160692 @default.
- W2013851403 hasAuthorship W2013851403A5056921442 @default.
- W2013851403 hasAuthorship W2013851403A5069925656 @default.
- W2013851403 hasAuthorship W2013851403A5078416571 @default.
- W2013851403 hasAuthorship W2013851403A5089704428 @default.
- W2013851403 hasConcept C104317684 @default.
- W2013851403 hasConcept C134018914 @default.
- W2013851403 hasConcept C139447449 @default.
- W2013851403 hasConcept C158617107 @default.
- W2013851403 hasConcept C170493617 @default.
- W2013851403 hasConcept C181199279 @default.
- W2013851403 hasConcept C185592680 @default.
- W2013851403 hasConcept C190283241 @default.
- W2013851403 hasConcept C2776151105 @default.
- W2013851403 hasConcept C2776989845 @default.
- W2013851403 hasConcept C2777847592 @default.
- W2013851403 hasConcept C2778004101 @default.
- W2013851403 hasConcept C2781331208 @default.
- W2013851403 hasConcept C28859421 @default.
- W2013851403 hasConcept C31573885 @default.
- W2013851403 hasConcept C48349386 @default.
- W2013851403 hasConcept C538909803 @default.
- W2013851403 hasConcept C54458228 @default.
- W2013851403 hasConcept C55493867 @default.