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• W201386325 abstract "Paclitaxel (Taxol #®) is one of the most promising new anticancer agents developed in recent years [1]. Taxol® has been approved for the treatment of refractory ovarian [2,3] and breast cancer [4] in several countries, and has shown activity against after human malignancies, such as lung cancer head and neck cancer, esophageal cancer, hematological malignancies, and melanomas. However, even in patients with responding tumors, response rates have not been superior to 50%, and relapses have always been the case, indicating that (1) even among the sensitive tumor types, there are examples of cancers that are naturally resistant to Taxol therapy (and these tumors are defined as having intrinsic resistance or insensitivity to Taxol, and (2) treatment with Taxol inexorably leads to development of resistance to paclitaxel (and these tumors are defined as having acquired resistance to Taxol). An understanding of the mechanisms of intrinsic or acquired resistance of cancer cells to paclitaxel can result in (1) design of better therapeutic modalities (drug combinations, sequences, schedule of treatment) for the treatment of cancer patients; (2) development of appropriate experimental models that represent as closely as possible the clinical cause of paclitaxel insensitivity or resistance; and (3) identification of novel anticancer drugs, and in particular paclitaxel analogs, active against paclitaxel-resistant cancer cells. An agent active against such tumor cells in vitro and in vivo would, in fact, be an important candidate for clinical development." @default.
• W201386325 created "2016-06-24" @default.
• W201386325 creator A5019693161 @default.
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• W201386325 date "1996-01-01" @default.
• W201386325 modified "2023-09-25" @default.
• W201386325 title "Paclitaxel (Taxol®) Mechanisms of Resistance" @default.
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• W201386325 doi "https://doi.org/10.1007/978-1-4613-1267-3_6" @default.
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