Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013872412> ?p ?o ?g. }
- W2013872412 endingPage "227" @default.
- W2013872412 startingPage "218" @default.
- W2013872412 abstract "Excess inhibition in the brain of individuals carrying an extra copy of chromosome 21 could be responsible for cognitive deficits observed throughout their lives. A change in the excitatory/inhibitory balance in adulthood would alter synaptic plasticity, potentially triggering learning and memory deficits. γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mature central nervous system and binds to GABAA receptors, opens a chloride channel, and reduces neuronal excitability. In this review we discuss methods to alleviate neuronal inhibition in a mouse model of Down syndrome, the Ts65Dn mouse, using either an antagonist (pentylenetetrazol) or two different inverse agonists selective for the α5-subunit containing receptor. Both inverse agonists, which reduce inhibitory GABAergic transmission, could rescue learning and memory deficits in Ts65Dn mice. We also discuss safety issues since modulation of the excitatory-inhibitory balance to improve cognition without inducing seizures remains particularly difficult when using GABA antagonists." @default.
- W2013872412 created "2016-06-24" @default.
- W2013872412 creator A5000769621 @default.
- W2013872412 creator A5063954532 @default.
- W2013872412 creator A5067992372 @default.
- W2013872412 date "2014-10-01" @default.
- W2013872412 modified "2023-10-18" @default.
- W2013872412 title "Treating enhanced GABAergic inhibition in Down syndrome: Use of GABA α5-selective inverse agonists" @default.
- W2013872412 cites W1496154065 @default.
- W2013872412 cites W1551663317 @default.
- W2013872412 cites W1565462218 @default.
- W2013872412 cites W1965334496 @default.
- W2013872412 cites W1968237042 @default.
- W2013872412 cites W1968536098 @default.
- W2013872412 cites W1968751712 @default.
- W2013872412 cites W1976853494 @default.
- W2013872412 cites W1977391603 @default.
- W2013872412 cites W1978074981 @default.
- W2013872412 cites W1980364661 @default.
- W2013872412 cites W1980798138 @default.
- W2013872412 cites W1983016215 @default.
- W2013872412 cites W1983372683 @default.
- W2013872412 cites W1986295842 @default.
- W2013872412 cites W1987201296 @default.
- W2013872412 cites W1987712339 @default.
- W2013872412 cites W1992834359 @default.
- W2013872412 cites W1996115552 @default.
- W2013872412 cites W1996154142 @default.
- W2013872412 cites W1996765504 @default.
- W2013872412 cites W1997288137 @default.
- W2013872412 cites W1997948920 @default.
- W2013872412 cites W1998665897 @default.
- W2013872412 cites W2000467859 @default.
- W2013872412 cites W2002708545 @default.
- W2013872412 cites W2004010919 @default.
- W2013872412 cites W2008492335 @default.
- W2013872412 cites W2012980780 @default.
- W2013872412 cites W2013775967 @default.
- W2013872412 cites W2014104667 @default.
- W2013872412 cites W2015303840 @default.
- W2013872412 cites W2016913270 @default.
- W2013872412 cites W2017160535 @default.
- W2013872412 cites W2017195170 @default.
- W2013872412 cites W2018461271 @default.
- W2013872412 cites W2019373887 @default.
- W2013872412 cites W2020117882 @default.
- W2013872412 cites W2021540664 @default.
- W2013872412 cites W2028064123 @default.
- W2013872412 cites W20326315 @default.
- W2013872412 cites W2032903160 @default.
- W2013872412 cites W2032953709 @default.
- W2013872412 cites W2034143722 @default.
- W2013872412 cites W2039738625 @default.
- W2013872412 cites W2040114944 @default.
- W2013872412 cites W2042887680 @default.
- W2013872412 cites W2043726039 @default.
- W2013872412 cites W2044521374 @default.
- W2013872412 cites W2050552159 @default.
- W2013872412 cites W2050717677 @default.
- W2013872412 cites W2051883633 @default.
- W2013872412 cites W2054351623 @default.
- W2013872412 cites W2054562862 @default.
- W2013872412 cites W2056060189 @default.
- W2013872412 cites W2058257681 @default.
- W2013872412 cites W2060890501 @default.
- W2013872412 cites W2061159864 @default.
- W2013872412 cites W2061366613 @default.
- W2013872412 cites W2062022610 @default.
- W2013872412 cites W2066536417 @default.
- W2013872412 cites W2066636162 @default.
- W2013872412 cites W2067777223 @default.
- W2013872412 cites W2068318808 @default.
- W2013872412 cites W2074126008 @default.
- W2013872412 cites W2077155977 @default.
- W2013872412 cites W2077273976 @default.
- W2013872412 cites W2081938027 @default.
- W2013872412 cites W2082869264 @default.
- W2013872412 cites W2083883439 @default.
- W2013872412 cites W2084233122 @default.
- W2013872412 cites W2084302868 @default.
- W2013872412 cites W2084520698 @default.
- W2013872412 cites W2086302274 @default.
- W2013872412 cites W2086398583 @default.
- W2013872412 cites W2087244575 @default.
- W2013872412 cites W2087519774 @default.
- W2013872412 cites W2088404776 @default.
- W2013872412 cites W2089790746 @default.
- W2013872412 cites W2090137827 @default.
- W2013872412 cites W2091486815 @default.
- W2013872412 cites W2095043290 @default.
- W2013872412 cites W2099268443 @default.
- W2013872412 cites W2101030003 @default.
- W2013872412 cites W2112200495 @default.
- W2013872412 cites W2112232226 @default.
- W2013872412 cites W2112877462 @default.
- W2013872412 cites W2118922355 @default.
- W2013872412 cites W2120497722 @default.
- W2013872412 cites W2121009504 @default.