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• W2013873957 abstract "Summary This study was designed to monitor lipid profile in the portal and hepatic blood of cows with fasting‐induced hepatic lipidosis, and to compare the results with those in the jugular blood. The work was also carried out to investigate bile acid (BA) in these vessels, and further to investigate BA extraction rate in the liver. Five cows were equipped with catheters in the portal, hepatic and jugular veins (day 0), fasted for 4 days (day 1–day 4) and then refed (day 5–day 11). Before morning feeding, blood was sampled before, during and after fasting from the catheterized vessels. In the portal blood, the concentration of non‐esterified fatty acids (NEFA) showed a progressive increase and at day 5 there was an approximate twofold rise. Increased NEFA concentrations were also found similarly in the other two veins. At day 5, β ‐hydroxybutyrate (BHBA) in the portal, hepatic and jugular blood rose to 197, 190 and 186% of the pre‐fasting value, respectively. However, the concentrations of NEFA and BHBA in the three veins gradually returned to pre‐fasting concentration during the refeeding period. Compared with the pre‐fasting value at day 0, the content of liver triglyceride (TG) increased significantly at day 5 ( P < 0.01). In the liver, the hepatic extraction rate of BA dropped from 3.1 times pre‐fasting to 2.2 times during fasting. There were no significant differences in the concentrations of glucose, TG, total cholesterol, cholesterol esters, free cholesterol and phospholipids. The results of the current study show that metabolic alterations occur in the portal, hepatic and jugular veins during induction of hepatic lipidosis in cows, and mostly metabolites, with exception of BA concentration, run parallel. The decreased BA extraction rate in the liver of fasted cows was considered to reflect hepatic cell impairment caused by TG accumulation. Hopefully, the findings, at least in part, contribute to the explanation of the pathophysiology of hepatic lipidosis in dairy cows." @default.
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• W2013873957 date "2004-04-01" @default.
• W2013873957 modified "2023-10-18" @default.
• W2013873957 title "Metabolic Profiles and Bile Acid Extraction Rate in the Liver of Cows with Fasting-induced Hepatic Lipidosis" @default.
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• W2013873957 doi "https://doi.org/10.1111/j.1439-0442.2004.00614.x" @default.
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