FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013875439> ?p ?o ?g. }

• W2013875439 endingPage "310" @default.
• W2013875439 startingPage "303" @default.
• W2013875439 abstract "Wobbler, the neurological mutant mouse, carries an autosomal recessive gene (wr) and has been characterized as a model of lower motoneuron disorders with associated muscle atrophy, denervation and reinnervation. During normal murine neuromuscular development a decrease in muscle plasminogen activator (PA) activity accompanies synapse maturation. In contrast, experimental denervation in adult mice leads to an increase in muscle PA activity. The purpose of the present study was to determine the possible involvement of PAs in the denervation/ reinnervation phenomena and motoneuron degeneration that characterize the wobbler mutant mouse. We determined the degree of innervation and its characteristics in wobbler mice by measuring choline acetyltransferase (ChAT) activity. We measured ChAT in the spinal cord as well as in two different muscles known to be differentially affected, biceps brachii and gastrocnemius. We found a sharp decrease of ChAT activity in both muscles but not in spinal cord extracts. We estimated the extent of sprouting by the silver/chilinesterase stain. Motoneuron terminal sprouting, not detected in normal animals, was present in 40% of the neuromuscular junctions in wobbler mice. We estimated specific PA activities in biceps brachii and gastrocnemius muscle extracts, as well as spinal cord extracts, using both an amidolytic assay and fibrin zymography. Increased PA, predominantly urokinase-PA (uPA), was observed in wobbler mouse muscle. A greater uPA was detected in biceps brachii muscle than in gastrocnemius muscle, which is less impaired by the mutation. There was no change in spinal cord PA, although tissue type PA (tPA) is the predominant PA type there. The present study demonstrates an activation of a specific serine protease, urokinase PA, in wobbler mouse muscle and may support the hypothesis of its involvement in the pathogenesis of lower motoneuron diseases." @default.
• W2013875439 created "2016-06-24" @default.
• W2013875439 creator A5008053832 @default.
• W2013875439 creator A5052732665 @default.
• W2013875439 creator A5054638711 @default.
• W2013875439 creator A5072610830 @default.
• W2013875439 creator A5077640627 @default.
• W2013875439 creator A5080020209 @default.
• W2013875439 creator A5090297236 @default.
• W2013875439 date "1992-05-01" @default.
• W2013875439 modified "2023-09-29" @default.
• W2013875439 title "Plasminogen activators in the neuromuscular system of the wobbler mutant mouse" @default.
• W2013875439 cites W1964980644 @default.
• W2013875439 cites W1968265833 @default.
• W2013875439 cites W1971316239 @default.
• W2013875439 cites W1979371835 @default.
• W2013875439 cites W1983058935 @default.
• W2013875439 cites W1996636157 @default.
• W2013875439 cites W1996886562 @default.
• W2013875439 cites W2004568599 @default.
• W2013875439 cites W2012606992 @default.
• W2013875439 cites W2023955930 @default.
• W2013875439 cites W2024779410 @default.
• W2013875439 cites W2027034777 @default.
• W2013875439 cites W2027487667 @default.
• W2013875439 cites W2034299466 @default.
• W2013875439 cites W2035665104 @default.
• W2013875439 cites W2040997641 @default.
• W2013875439 cites W2045690462 @default.
• W2013875439 cites W2050320053 @default.
• W2013875439 cites W2052411264 @default.
• W2013875439 cites W2055024913 @default.
• W2013875439 cites W2056090701 @default.
• W2013875439 cites W2061476071 @default.
• W2013875439 cites W2064895958 @default.
• W2013875439 cites W2068624139 @default.
• W2013875439 cites W2076873375 @default.
• W2013875439 cites W2087412988 @default.
• W2013875439 cites W2092762288 @default.
• W2013875439 cites W2093608710 @default.
• W2013875439 cites W2100837269 @default.
• W2013875439 cites W2118570039 @default.
• W2013875439 cites W2119837316 @default.
• W2013875439 cites W2130824580 @default.
• W2013875439 cites W2134311390 @default.
• W2013875439 cites W2137900251 @default.
• W2013875439 cites W2162567095 @default.
• W2013875439 cites W23122061 @default.
• W2013875439 cites W4293247451 @default.
• W2013875439 doi "https://doi.org/10.1016/0006-8993(92)90958-c" @default.
• W2013875439 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1504807" @default.
• W2013875439 hasPublicationYear "1992" @default.
• W2013875439 type Work @default.
• W2013875439 sameAs 2013875439 @default.
• W2013875439 citedByCount "23" @default.
• W2013875439 countsByYear W20138754392013 @default.
• W2013875439 countsByYear W20138754392019 @default.
• W2013875439 countsByYear W20138754392021 @default.
• W2013875439 crossrefType "journal-article" @default.
• W2013875439 hasAuthorship W2013875439A5008053832 @default.
• W2013875439 hasAuthorship W2013875439A5052732665 @default.
• W2013875439 hasAuthorship W2013875439A5054638711 @default.
• W2013875439 hasAuthorship W2013875439A5072610830 @default.
• W2013875439 hasAuthorship W2013875439A5077640627 @default.
• W2013875439 hasAuthorship W2013875439A5080020209 @default.
• W2013875439 hasAuthorship W2013875439A5090297236 @default.
• W2013875439 hasConcept C105702510 @default.
• W2013875439 hasConcept C126322002 @default.
• W2013875439 hasConcept C134018914 @default.
• W2013875439 hasConcept C169760540 @default.
• W2013875439 hasConcept C198399640 @default.
• W2013875439 hasConcept C2775910092 @default.
• W2013875439 hasConcept C2776805190 @default.
• W2013875439 hasConcept C2777240379 @default.
• W2013875439 hasConcept C2779649809 @default.
• W2013875439 hasConcept C2780775167 @default.
• W2013875439 hasConcept C2781425419 @default.
• W2013875439 hasConcept C71924100 @default.
• W2013875439 hasConcept C86803240 @default.
• W2013875439 hasConceptScore W2013875439C105702510 @default.
• W2013875439 hasConceptScore W2013875439C126322002 @default.
• W2013875439 hasConceptScore W2013875439C134018914 @default.
• W2013875439 hasConceptScore W2013875439C169760540 @default.
• W2013875439 hasConceptScore W2013875439C198399640 @default.
• W2013875439 hasConceptScore W2013875439C2775910092 @default.
• W2013875439 hasConceptScore W2013875439C2776805190 @default.
• W2013875439 hasConceptScore W2013875439C2777240379 @default.
• W2013875439 hasConceptScore W2013875439C2779649809 @default.
• W2013875439 hasConceptScore W2013875439C2780775167 @default.
• W2013875439 hasConceptScore W2013875439C2781425419 @default.
• W2013875439 hasConceptScore W2013875439C71924100 @default.
• W2013875439 hasConceptScore W2013875439C86803240 @default.
• W2013875439 hasIssue "1-2" @default.
• W2013875439 hasLocation W20138754391 @default.
• W2013875439 hasLocation W20138754392 @default.
• W2013875439 hasOpenAccess W2013875439 @default.
• W2013875439 hasPrimaryLocation W20138754391 @default.
• W2013875439 hasRelatedWork W2013875439 @default.

• next