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- W2013884037 abstract "The effects of recombinant interleukin 1 alpha and beta, as well as recombinant interleukin 2, on human keratinocyte proliferation were studied in serum-containing as well as defined media. Both interleukin 1 preparations did not stimulate keratinocyte growth; interleukin 2 also did not stimulate keratinocyte growth. To determine whether interleukin 1 beta binds to keratinocytes, a cell membrane assay was developed for these cells. Iodinated interleukin 1 beta binds to keratinocytes with a kD of 6.2 nm and 2500 receptors per cell. To determine the effects of interleukin 1 beta on protein synthesis, the molecular patterns of radiolabeled cell extracts of interleukin 1 beta-treated and nontreated keratinocytes were compared using two-dimensional polyacrylamide gel electrophoresis. No significant changes in the molecular pattern of newly synthesized proteins were detected. Finally, none of these lymphokines induced HLA-DR expression by keratinocytes." @default.
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- W2013884037 date "1989-07-01" @default.
- W2013884037 modified "2023-09-25" @default.
- W2013884037 title "Effects of Recombinant Interleukin 1 and Interleukin 2 on Human Keratinocytes" @default.
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- W2013884037 doi "https://doi.org/10.1111/1523-1747.ep12277378" @default.
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