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- W2013886729 abstract "LHRH or agonist analogs terminate pregnancy when administered pre- or postimplantationally. Also, LHRH can exert this effect independent of the pituitary after day 12 (D12) of pregnancy in the rat, when the pituitary is unnecessary for gestational support. The present study, using LHRH and the potent agonist, D-AlaB6-des-Gly10-Pr9-NHEt-LHRH (Wy- 18,481), confirms this extrapituitary antifertility activity and describes associated changes in placental and luteal function, as determined by serum rat placental lactogen (rPL) and serum progesterone (P), respectively. An initial study in intact pregnant rats indicated that the administration of 500 fig LHRH/day between D7–12 produced a decrease in serum rPL which was associated with the termination of pregnancy induced by this treatment and coincident with a fall in P. In an effort to determine whether the inhibition of rPL represented a direct effect of the LH-releasing peptide, daily sc administration of 500 μg LHRH or 50 jug Wy-18,481 was begun immediately ..." @default.
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- W2013886729 date "1981-01-01" @default.
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- W2013886729 title "Luteinizing Hormone-Releasing Hormone (LHRH) and LHRH Agonist Termination of Pregnancy in Hypophysectomized Rats: Extrapituitary Site of Action*" @default.
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- W2013886729 doi "https://doi.org/10.1210/endo-108-1-273" @default.
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