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• W2013889215 abstract "<i>Objective:</i> To observe whether or not the small-interfering RNA (siRNA) that conjugated with human immunodeficiency virus type 1 (HIV-1) TAT_47–57 peptides can enter Huh-7 cells and efficiently silence hepatitis C virus (HCV) infection in cell culture. <i>Methods:</i> siRNA targeting the highly conserved stem loop IV of the HCV 5′ untranslated region (5′UTR) was conjugated to TAT_47–57 peptides via the crosslinker sulfosuccinimidyl-4-(p-maleimidophenyl)-butyrate, and then the conjugates were added to the Huh-7 cell culture. Firefly luciferase activity and HCV RNA were asssessed using a luciferase assay reagent and real-time reverse transcript polymerase chain reaction, respectively. <i>Results:</i> The expression of firefly luciferase in HCV replicons and the concentration of HCV RNA were downregulated by siRNA-TAT_47–57, and siRNA-TAT_47–57 mediated RNA interfering activity which was directly correlated with increasing concentrations of the siRNA-TAT_47–57 conjugate used. <i>Conclusion:</i> Cell-penetrating peptides such as HIV-1 TAT are an effective method for the delivery of siRNA targeted at 5′UTR of HCV in mammalian cells." @default.
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• W2013889215 date "2009-01-01" @default.
• W2013889215 modified "2023-10-16" @default.
• W2013889215 title "TAT Peptides Mediated Small Interfering RNA Delivery to Huh-7 Cells and Efficiently Inhibited Hepatitis C Virus RNA Replication" @default.
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• W2013889215 doi "https://doi.org/10.1159/000220597" @default.
• W2013889215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19478527" @default.
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