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• W2013896290 abstract "In 1988, the Clinical Center at the n’ational Institutes of Health elected to offer post-exposure antiretroviral chemoprophylaxis with the then novel antiviral agent, 3’-azido-3’-deoxythymidine (zidovudine, ZDV) to healthcare workers who had sustained occupational exposures to the Human Immunodeficiency Virus (HIV). Th’ d 1s ecision was made, in great measure, in response to an occupational exposure and infection that occurred in the Department of Transfusion Medicine at the Clinical Center.‘12 Although a few institutions, most notably The University of California at San Francisco’s San Francisco General Hospital,3 began offering post-exposure chemoprophylaxis with ZDV at approximately the same time, other authorities were highly skeptical about the use of antiretroviral agents in this setting.&’ Concerns were expressed about: the potential toxicities of antiretroviral agents in otherwise healthy healthcare workers;’ the fact that the mechanism of action of available antiretroviral agents at the time was not optimal for chemoprophylaxis and that these drugs might mask the clinical and serologic manifestations of HIV infection in exposed healthcare workers;‘a7 the documented failures of zidovudine to prevent HIV infection in specific instances;6’8-‘6 the apparently lessthan-optimal mechanism of action of available antiretrovirals; the potential for fostering viral resistance as a result of increased use;” and the ethics of administering agents for off-label use in a circumstance filled with fear and emotion.5 Each of these concerns was, and remains, legitimate. Ten years later, a substantial body of data has been amassed that provides encouraging, albeit indirect, support for institutions electing to offer post-exposure antiretroviral chemoprophylaxis for healthcare workers’ occupational exposures to HIV. Whereas the data collected over the past several years fall short of definitive proof of the efficacy of post-exposure antiretroviral chemoprophylaxis, these data do make a reasonably compelling argument for offering these agents for occupational HIV exposures. Table I lists the categories of information that, taken together, constitute the rationale for offering post-exposure antiretroviral chemoprophylaxis." @default.
• W2013896290 created "2016-06-24" @default.
• W2013896290 creator A5002184999 @default.
• W2013896290 date "1999-12-01" @default.
• W2013896290 modified "2023-09-23" @default.
• W2013896290 title "Weighing the consequence of doing nothing versus those of doing something: post-exposure chemoprophylaxis for occupational exposures to HIV" @default.
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• W2013896290 doi "https://doi.org/10.1016/s0195-6701(99)90091-9" @default.
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