FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013904418> ?p ?o ?g. }

• W2013904418 endingPage "1046" @default.
• W2013904418 startingPage "1039" @default.
• W2013904418 abstract "B cell chronic lymphocytic leukemia (CLL) is a malignancy of the CD5+ B cells. Prior studies indicated that CLL B cells generally express immunoglobulin (Ig) VH and VL genes with little or no somatic mutations. However, a recent report indicated that VH251, one of three VH genes belonging to the VH5 subgroup (e.g., VH251, VH32, and VH15), not only is frequently rearranged in this disease, but also has extensive and selective mutations when expressed by CLL B cells. The extent and nature of these mutations contrasts markedly from the low level of mutations noted in VH5 genes used by normal B cells or other Ig V genes found expressed in CLL. To determine whether this difference reflects a unique property of VH251 or a previously unrecognized subgroup of CLL, we examined for VH5 Ig gene rearrangements in leukemia cells from 68 patients that satisfied clinical and diagnostic criteria for CD5+ B cell CLL. Southern blot hybridization studies with probes for VH251 and the JH locus revealed that only 7 (10%) of the 68 monoclonal CLL cell populations had undergone Ig gene rearrangement involving VH5 genes. Two (3%) were found to have functionally rearranged VH5 genes that shared > or = 98% sequence homology with 5-2R1, a VH251 gene isolated from a pre-B cell acute lymphocytic leukemia. The other five CLL (7%) had functionally rearranged VH5 genes that each shared > or = 99% nucleic acid sequence homology with a germline VH32 isolated from human sperm DNA. These data indicate that VH251 or VH32 also may be expressed by CD5+ CLL B cells with little or no somatic mutation. These findings contrast with a recently published study on VH5 gene expression in B CLL and contest the hypothesis that extensive somatic mutation is a common property of the VH5 genes used in this disease. Further work to define the clinical and/or phenotypic characteristics of patients with leukemia cells that express mutated versus nonmutated Ig V genes may reveal subsets of CLL that possibly differ in their cytogenesis, etiopathogenesis, and/or clinical behavior." @default.
• W2013904418 created "2016-06-24" @default.
• W2013904418 creator A5010336471 @default.
• W2013904418 creator A5036828560 @default.
• W2013904418 date "1993-04-01" @default.
• W2013904418 modified "2023-10-16" @default.
• W2013904418 title "Lack of extensive mutations in the VH5 genes used in common B cell chronic lymphocytic leukemia." @default.
• W2013904418 cites W1482733938 @default.
• W2013904418 cites W1516636900 @default.
• W2013904418 cites W1532305791 @default.
• W2013904418 cites W154103547 @default.
• W2013904418 cites W1546739249 @default.
• W2013904418 cites W1558516755 @default.
• W2013904418 cites W1580036772 @default.
• W2013904418 cites W1608668075 @default.
• W2013904418 cites W161233626 @default.
• W2013904418 cites W1658761436 @default.
• W2013904418 cites W1880155747 @default.
• W2013904418 cites W194705401 @default.
• W2013904418 cites W1974349758 @default.
• W2013904418 cites W1975712548 @default.
• W2013904418 cites W1980075357 @default.
• W2013904418 cites W1980863088 @default.
• W2013904418 cites W1992595091 @default.
• W2013904418 cites W2014669590 @default.
• W2013904418 cites W2015086833 @default.
• W2013904418 cites W2016057691 @default.
• W2013904418 cites W2021672579 @default.
• W2013904418 cites W2028920820 @default.
• W2013904418 cites W2028954926 @default.
• W2013904418 cites W2039979639 @default.
• W2013904418 cites W2054040503 @default.
• W2013904418 cites W2072926499 @default.
• W2013904418 cites W2080160583 @default.
• W2013904418 cites W2090199761 @default.
• W2013904418 cites W2090711712 @default.
• W2013904418 cites W2105441566 @default.
• W2013904418 cites W2107235432 @default.
• W2013904418 cites W2127615035 @default.
• W2013904418 cites W2129077978 @default.
• W2013904418 cites W2135387211 @default.
• W2013904418 cites W2154830637 @default.
• W2013904418 cites W2164503950 @default.
• W2013904418 cites W2186589950 @default.
• W2013904418 cites W2275727528 @default.
• W2013904418 cites W2412439447 @default.
• W2013904418 cites W2414763687 @default.
• W2013904418 cites W2417426135 @default.
• W2013904418 cites W2425928703 @default.
• W2013904418 cites W2432381680 @default.
• W2013904418 cites W2434826450 @default.
• W2013904418 cites W28190658 @default.
• W2013904418 cites W292110951 @default.
• W2013904418 cites W89133373 @default.
• W2013904418 cites W2067877054 @default.
• W2013904418 doi "https://doi.org/10.1084/jem.177.4.1039" @default.
• W2013904418 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2190987" @default.
• W2013904418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7681468" @default.
• W2013904418 hasPublicationYear "1993" @default.
• W2013904418 type Work @default.
• W2013904418 sameAs 2013904418 @default.
• W2013904418 citedByCount "46" @default.
• W2013904418 countsByYear W20139044182012 @default.
• W2013904418 countsByYear W20139044182021 @default.
• W2013904418 crossrefType "journal-article" @default.
• W2013904418 hasAuthorship W2013904418A5010336471 @default.
• W2013904418 hasAuthorship W2013904418A5036828560 @default.
• W2013904418 hasBestOaLocation W20139044181 @default.
• W2013904418 hasConcept C104317684 @default.
• W2013904418 hasConcept C109825262 @default.
• W2013904418 hasConcept C113067387 @default.
• W2013904418 hasConcept C153911025 @default.
• W2013904418 hasConcept C159654299 @default.
• W2013904418 hasConcept C2777938653 @default.
• W2013904418 hasConcept C2778453870 @default.
• W2013904418 hasConcept C2778461978 @default.
• W2013904418 hasConcept C54355233 @default.
• W2013904418 hasConcept C86803240 @default.
• W2013904418 hasConceptScore W2013904418C104317684 @default.
• W2013904418 hasConceptScore W2013904418C109825262 @default.
• W2013904418 hasConceptScore W2013904418C113067387 @default.
• W2013904418 hasConceptScore W2013904418C153911025 @default.
• W2013904418 hasConceptScore W2013904418C159654299 @default.
• W2013904418 hasConceptScore W2013904418C2777938653 @default.
• W2013904418 hasConceptScore W2013904418C2778453870 @default.
• W2013904418 hasConceptScore W2013904418C2778461978 @default.
• W2013904418 hasConceptScore W2013904418C54355233 @default.
• W2013904418 hasConceptScore W2013904418C86803240 @default.
• W2013904418 hasIssue "4" @default.
• W2013904418 hasLocation W20139044181 @default.
• W2013904418 hasLocation W20139044182 @default.
• W2013904418 hasLocation W20139044183 @default.
• W2013904418 hasLocation W20139044184 @default.
• W2013904418 hasLocation W20139044185 @default.
• W2013904418 hasOpenAccess W2013904418 @default.
• W2013904418 hasPrimaryLocation W20139044181 @default.
• W2013904418 hasRelatedWork W1999472575 @default.
• W2013904418 hasRelatedWork W2119320736 @default.

• next