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- W2013904489 abstract "Previous studies suggested an involvement of γ-aminobutyric acid (GABA)-mediated excitation by an enhanced efflux of bicarbonate ions in addition to retarded development of GABAergic inhibition in the syndrome of dtsz mutant hamsters, a model of paroxysmal dyskinesia in which dystonic episodes occur in response to stress. Acetazolamide blocks bicarbonate regeneration in neurons and can thereby reduce GABA-mediating excitation without affecting GABA-mediated inhibition. In the present study, the effects of acetazolamide (15–60 mg/kg, i.p.) on severity of dystonia were therefore examined in dtsz hamsters. Acetazolamide significantly reduced the severity of dystonia at a dose of 60 mg/kg. These data are in line with several case reports from patients with paroxysmal dystonia, suggesting that acetazolamide can be useful in the treatment of this movement disorder. The mechanism of the antidystonic efficacy of acetazolamide has to be examined by further studies." @default.
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- W2013904489 date "2004-10-01" @default.
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- W2013904489 title "The carbonic anhydrase inhibitor acetazolamide exerts antidystonic effects in the dtsz mutant hamster" @default.
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- W2013904489 doi "https://doi.org/10.1016/j.ejphar.2004.08.017" @default.
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