FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013904750> ?p ?o ?g. }

• W2013904750 endingPage "295" @default.
• W2013904750 startingPage "281" @default.
• W2013904750 abstract "X-ray crystallography has been used to examine the binding of three members of the beta-lactam family of antibiotics to the D-alanyl-D-alanine peptidase from Streptomyces R61, a target of penicillins. Cephalosporin C, the monobactam analog of penicillin G and (2,3)-alpha-methylene benzylpenicillin have been mapped at 2.3 A resolution in the form of acyl-enzyme complexes bound to serine 62. On the basis of the positions of these inhibitors, the binding of a tripeptide substrate for the enzyme, L-lysyl-D-alanyl-D-alanine, has been modeled in the active site. The binding of both inhibitors and substrate is facilitated by hydrogen-bonding interactions with a conserved beta-strand (297-303), which is antiparallel to the beta-lactam's acylamide linkage or the substrate's peptide bond. The active site is similar to that in beta-lactamases." @default.
• W2013904750 created "2016-06-24" @default.
• W2013904750 creator A5009805190 @default.
• W2013904750 creator A5026727477 @default.
• W2013904750 creator A5031770694 @default.
• W2013904750 creator A5078147117 @default.
• W2013904750 creator A5085205603 @default.
• W2013904750 date "1989-09-01" @default.
• W2013904750 modified "2023-09-24" @default.
• W2013904750 title "Crystallographic mapping of β-lactams bound to a d-alanyl-d-alanine peptidase target enzyme" @default.
• W2013904750 cites W1532698711 @default.
• W2013904750 cites W168483134 @default.
• W2013904750 cites W1764629353 @default.
• W2013904750 cites W1922438834 @default.
• W2013904750 cites W1965606033 @default.
• W2013904750 cites W1967601334 @default.
• W2013904750 cites W1969932198 @default.
• W2013904750 cites W1974178486 @default.
• W2013904750 cites W1978382870 @default.
• W2013904750 cites W1980616168 @default.
• W2013904750 cites W1982455140 @default.
• W2013904750 cites W1984515631 @default.
• W2013904750 cites W1987416093 @default.
• W2013904750 cites W1995464211 @default.
• W2013904750 cites W1996132840 @default.
• W2013904750 cites W2026130809 @default.
• W2013904750 cites W2036331995 @default.
• W2013904750 cites W2042239767 @default.
• W2013904750 cites W2044647783 @default.
• W2013904750 cites W2045301115 @default.
• W2013904750 cites W2052928475 @default.
• W2013904750 cites W2064699133 @default.
• W2013904750 cites W2066459154 @default.
• W2013904750 cites W2080539912 @default.
• W2013904750 cites W2112636022 @default.
• W2013904750 cites W2117514600 @default.
• W2013904750 cites W2124768653 @default.
• W2013904750 cites W2163015606 @default.
• W2013904750 cites W2178936247 @default.
• W2013904750 doi "https://doi.org/10.1016/0022-2836(89)90277-5" @default.
• W2013904750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2585485" @default.
• W2013904750 hasPublicationYear "1989" @default.
• W2013904750 type Work @default.
• W2013904750 sameAs 2013904750 @default.
• W2013904750 citedByCount "105" @default.
• W2013904750 countsByYear W20139047502013 @default.
• W2013904750 countsByYear W20139047502014 @default.
• W2013904750 countsByYear W20139047502017 @default.
• W2013904750 countsByYear W20139047502018 @default.
• W2013904750 countsByYear W20139047502019 @default.
• W2013904750 countsByYear W20139047502023 @default.
• W2013904750 crossrefType "journal-article" @default.
• W2013904750 hasAuthorship W2013904750A5009805190 @default.
• W2013904750 hasAuthorship W2013904750A5026727477 @default.
• W2013904750 hasAuthorship W2013904750A5031770694 @default.
• W2013904750 hasAuthorship W2013904750A5078147117 @default.
• W2013904750 hasAuthorship W2013904750A5085205603 @default.
• W2013904750 hasBestOaLocation W20139047502 @default.
• W2013904750 hasConcept C107824862 @default.
• W2013904750 hasConcept C112887158 @default.
• W2013904750 hasConcept C115260700 @default.
• W2013904750 hasConcept C121332964 @default.
• W2013904750 hasConcept C142089489 @default.
• W2013904750 hasConcept C167392928 @default.
• W2013904750 hasConcept C174802600 @default.
• W2013904750 hasConcept C178790620 @default.
• W2013904750 hasConcept C181199279 @default.
• W2013904750 hasConcept C185592680 @default.
• W2013904750 hasConcept C18903297 @default.
• W2013904750 hasConcept C2776341680 @default.
• W2013904750 hasConcept C2776414213 @default.
• W2013904750 hasConcept C2776653525 @default.
• W2013904750 hasConcept C2777289219 @default.
• W2013904750 hasConcept C2779281246 @default.
• W2013904750 hasConcept C2779856020 @default.
• W2013904750 hasConcept C32909587 @default.
• W2013904750 hasConcept C41183919 @default.
• W2013904750 hasConcept C501593827 @default.
• W2013904750 hasConcept C515207424 @default.
• W2013904750 hasConcept C55493867 @default.
• W2013904750 hasConcept C62520636 @default.
• W2013904750 hasConcept C71240020 @default.
• W2013904750 hasConcept C8010536 @default.
• W2013904750 hasConcept C86803240 @default.
• W2013904750 hasConceptScore W2013904750C107824862 @default.
• W2013904750 hasConceptScore W2013904750C112887158 @default.
• W2013904750 hasConceptScore W2013904750C115260700 @default.
• W2013904750 hasConceptScore W2013904750C121332964 @default.
• W2013904750 hasConceptScore W2013904750C142089489 @default.
• W2013904750 hasConceptScore W2013904750C167392928 @default.
• W2013904750 hasConceptScore W2013904750C174802600 @default.
• W2013904750 hasConceptScore W2013904750C178790620 @default.
• W2013904750 hasConceptScore W2013904750C181199279 @default.
• W2013904750 hasConceptScore W2013904750C185592680 @default.
• W2013904750 hasConceptScore W2013904750C18903297 @default.
• W2013904750 hasConceptScore W2013904750C2776341680 @default.
• W2013904750 hasConceptScore W2013904750C2776414213 @default.
• W2013904750 hasConceptScore W2013904750C2776653525 @default.

• next