Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013906543> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2013906543 endingPage "1198" @default.
- W2013906543 startingPage "1195" @default.
- W2013906543 abstract "Abstract Intravenous injection of 2.0 ml of a suspension of killed E . coli cell bodies produced a robust biphasic febrile response in the rhesus monkey. Intracerebral injection of the same pyrogen at 1/4000 of the intravenous dose produced a quite similar biphasic febrile effect. When administered i.v., this low dose had no effect on body temperature. Thirteen of the 16 sites (81 %) whose stimulation with endotoxin evoked a biphasic fever were located within 4 mm of the midpoint between the optic chiasm and the decussation of the anterior commissure. The second peak of the biphasic response to i.v. administered endotoxin is generally considered to be due to an endogenous pyrogen, released from leukocytes in the periphery, which penetrates the blood-brain barrier to act directly upon central thermoregulatory mechanisms. The present findings indicate that the entire biphasic response can be reproduced by an action of endotoxin within the CNS. Thus, it is possible that a portion of the second phase of a fever evoked by endotoxin injected i.v. may be due to a release of endogenous pyrogen within the brain, rather than within the bloodstream." @default.
- W2013906543 created "2016-06-24" @default.
- W2013906543 creator A5029172289 @default.
- W2013906543 creator A5042389999 @default.
- W2013906543 creator A5069375929 @default.
- W2013906543 date "1973-12-01" @default.
- W2013906543 modified "2023-10-12" @default.
- W2013906543 title "Evocation of a biphasic febrile response in the rhesus monkey by intracerebral injection of bacterial endotoxins" @default.
- W2013906543 cites W2014118059 @default.
- W2013906543 cites W2027886306 @default.
- W2013906543 cites W2041704329 @default.
- W2013906543 cites W2132996589 @default.
- W2013906543 cites W2171609043 @default.
- W2013906543 cites W2266295784 @default.
- W2013906543 cites W2396380695 @default.
- W2013906543 cites W2397943329 @default.
- W2013906543 doi "https://doi.org/10.1016/0028-3908(73)90077-4" @default.
- W2013906543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4205774" @default.
- W2013906543 hasPublicationYear "1973" @default.
- W2013906543 type Work @default.
- W2013906543 sameAs 2013906543 @default.
- W2013906543 citedByCount "9" @default.
- W2013906543 crossrefType "journal-article" @default.
- W2013906543 hasAuthorship W2013906543A5029172289 @default.
- W2013906543 hasAuthorship W2013906543A5042389999 @default.
- W2013906543 hasAuthorship W2013906543A5069375929 @default.
- W2013906543 hasConcept C138885662 @default.
- W2013906543 hasConcept C15744967 @default.
- W2013906543 hasConcept C169760540 @default.
- W2013906543 hasConcept C27206212 @default.
- W2013906543 hasConcept C2780217361 @default.
- W2013906543 hasConcept C42219234 @default.
- W2013906543 hasConcept C71924100 @default.
- W2013906543 hasConceptScore W2013906543C138885662 @default.
- W2013906543 hasConceptScore W2013906543C15744967 @default.
- W2013906543 hasConceptScore W2013906543C169760540 @default.
- W2013906543 hasConceptScore W2013906543C27206212 @default.
- W2013906543 hasConceptScore W2013906543C2780217361 @default.
- W2013906543 hasConceptScore W2013906543C42219234 @default.
- W2013906543 hasConceptScore W2013906543C71924100 @default.
- W2013906543 hasIssue "12" @default.
- W2013906543 hasLocation W20139065431 @default.
- W2013906543 hasLocation W20139065432 @default.
- W2013906543 hasOpenAccess W2013906543 @default.
- W2013906543 hasPrimaryLocation W20139065431 @default.
- W2013906543 hasRelatedWork W1506200166 @default.
- W2013906543 hasRelatedWork W2039318446 @default.
- W2013906543 hasRelatedWork W2080531066 @default.
- W2013906543 hasRelatedWork W2373165440 @default.
- W2013906543 hasRelatedWork W2393704585 @default.
- W2013906543 hasRelatedWork W2549135832 @default.
- W2013906543 hasRelatedWork W2748952813 @default.
- W2013906543 hasRelatedWork W2899084033 @default.
- W2013906543 hasRelatedWork W3032375762 @default.
- W2013906543 hasRelatedWork W3108674512 @default.
- W2013906543 hasVolume "12" @default.
- W2013906543 isParatext "false" @default.
- W2013906543 isRetracted "false" @default.
- W2013906543 magId "2013906543" @default.
- W2013906543 workType "article" @default.