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- W2013906581 abstract "Objective: Aneuploidy, one of the major reasons for embryo loss after implantation, originates during meiosis in oocytes and occurs frequently in the oocytes of women of advanced maternal age. It has been postulated that aneuploidy occurs because the germinal vesicle (GV) nucleus in these eggs is maturing in an unhealthy cytoplasm leading to an irregular structure of the meiotic spindle. However, if one is to test this hypothesis one must show that the GV can mature normally in healthy cytoplasm. In mouse eggs the incidence of aneuploidy is 100+-fold lower than is observed in humans. In this study we examine whether mouse ooplasts can be used to investigate the ooplasm’s impact on a human GV’s progression through meiosis." @default.
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- W2013906581 date "2002-09-01" @default.
- W2013906581 modified "2023-09-29" @default.
- W2013906581 title "Germinal vesicle xeno-transfer between mouse and human oocytes: A model to study ooplasmic influences on meiotic division" @default.
- W2013906581 doi "https://doi.org/10.1016/s0015-0282(02)03583-5" @default.
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