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• W2013910902 abstract "Fifty-four very-low birth weight (VLBW) infants with proved or suspected septicemia hospitalized in the neonatal intensive care unit in Asahikawa Kosei Hospital were treated empirically with imipenem/cilastatin sodium (IPM/CS). IPM/CS was infused over a 30-minute period at a mean dose of 20.1±1.1 mg/kg (range, 17.4 to 23.4 mg/kg) and given every 12 hours for a period of 6.1±3.1 days (range, 3 to 16 days). The gestational age of the infants was 26.6±2.1 weeks (range, 24.0 to 31.0 weeks) and their birth weight was 860±234 g (range, 536 to 1478 g). At the time of initial administration of IPM/CS, the age was 30.5±2.9 days (range, 2 to 77 days), and the body weight was 799±289 g (range, 422 to 1748 g). Though 29 patients were administered IPM/CS on suspicion of septicemia, the causative organism could not be isolated. Causative organisms were isolated from the blood in 25 of the 54 patients, and includedAcinetobacter calcoaceticus (n=7),Enterobacter cloacae (n=5), methicillin-resistantStaphylococcus aureus (MRSA; n=5), other gram-negative bacilli (n=5),Staphylococcus epidermidis (n=2), MRSA andKlebsiella pneumoniae (n=1). A clinical cure was achieved in 17 of 25 infants and improvement was noted in an additional 3 infants, while 5 infants were evaluated as treatment failures. The 5 treatment failure patients were all diagnosed with MRSA infections. No adverse effects or abnormal laboratory values due to IPM/CS therapy were observed in these infants." @default.
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• W2013910902 date "1996-01-01" @default.
• W2013910902 modified "2023-09-25" @default.
• W2013910902 title "Treatment of Septicemia with Imipenem/Cilastatin Sodium in Very-Low Birth Weight Infants" @default.
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• W2013910902 doi "https://doi.org/10.1007/bf02351572" @default.
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