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- W2013914369 abstract "The present study was conducted to evaluate the effect of L-3, 4-dihydroxyphenylalanine (L-DOPA) on the daily rhythms of temperature, heart rate and locomotor activity in rats that received a 7-day continuous infusion. Our results indicate that L-DOPA does not induce a loss of the daily rhythmicity of temperature, heart rate and locomotor activity but modifies the main parameters of these rhythms, e.g. it increased the MESOR (midline estimating statistic of rhythm) of temperature and heart rate and increased the amplitude of temperature but decreased the amplitude of heart rate. Taking into account these results obtained after constant rate delivery, we now plan to investigate the effects of DOPA therapy by changing the time of its administration." @default.
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- W2013914369 date "2000-07-01" @default.
- W2013914369 modified "2023-09-27" @default.
- W2013914369 title "Effects of a seven-day continuous infusion of l-DOPA on daily rhythms in the rat" @default.
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- W2013914369 doi "https://doi.org/10.1016/s0014-2999(00)00422-2" @default.
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