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- W2013925300 abstract "Abstract The biliary excretion of six bis-quaternary ammonium compounds, alcuronoum (Alloferine®), dimethyltubocurarine, gallamine, hexafluorenium (Mylaxen®), pancuronium (Pavulon®) and d-tubocurarine was studied in the isolated perfused rat liver. Thin-layer chromatography of bile samples showed great differences in transport into bile. Hexafluorenium and d-tubocurarine are excreted to a large extent but only very small amounts of the other compounds appeared in bile. The lipophilic character of the compounds was estimated by shaking various aqueous solutions with octan-1-ol. Passage into the organic solvent of d-tubocurarine but not of the other agents was influenced by the pH of the aqueous phase. Only hexafluorenium and d-tubocurarine could be extracted into the organic solvent to a significant degree, suggesting that lipid solubility is an important factor in the transport of bis-quaternary ammonium compounds from plasma to bile." @default.
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- W2013925300 modified "2023-09-24" @default.
- W2013925300 title "Curare-like agents: Relation between lipid solubility and transport into bile in perfused rat liver" @default.
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- W2013925300 doi "https://doi.org/10.1016/0014-2999(70)90284-0" @default.
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