FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013928330> ?p ?o ?g. }

• W2013928330 endingPage "2813" @default.
• W2013928330 startingPage "2807" @default.
• W2013928330 abstract "Because of their similarities to infants in mucosal immune responses and their susceptibility to human rotavirus (HRV) diarrhea, gnotobiotic pigs provide a useful model for rotaviral disease. In this study, we performed quantitative enzyme-linked immunospot (ELISPOT) assays to measure local and systemic isotype-specific antibody-secreting cell (ASC) responses to individual structural (VP4, VP6, and VP7) and nonstructural (NSP3 and NSP4) proteins of Wa HRV. The Spodoptera frugiperda cells expressing each recombinant baculovirus HRV protein were formalin fixed and used as antigen for ELISPOT assays. Neonatal gnotobiotic pigs were orally inoculated once with virulent Wa (WaV) or three times with attenuated Wa (WaA) HRV or mock inoculated (Mock) and then were challenged with virulent Wa (WaV/PC) 28 days after the first inoculation. The ASCs from intestinal and systemic lymphoid tissues of pigs from each group were quantitated by ELISPOT assay at the day of challenge, at postinoculation day 28 (WaV, WaA, and Mock) or at postchallenge day (PCD) 7 (WaV+WaV/PC, WaA+WaV/PC, and Mock+WaV/PC). In all virus-inoculated pigs, regardless of the inoculum, lymphoid tissue, or isotype, VP6 induced the highest numbers of ASCs, followed by VP4; ASCs specific for VP7, NSP3, and NSP4 were less numerous. At challenge, total HRV- and HRV protein-specific immunoglobulin A (IgA) and IgG ASCs in intestinal lymphoid tissues were significantly greater in WaV- than in WaA-inoculated pigs, and WaV pigs were fully protected against diarrhea postchallenge, whereas the WaA pigs were partially protected. At PCD 7, there were no significant differences in ASC numbers for any HRV proteins between the WaV+WaV/PC and WaA+WaV/PC groups." @default.
• W2013928330 created "2016-06-24" @default.
• W2013928330 creator A5021738815 @default.
• W2013928330 creator A5029022788 @default.
• W2013928330 creator A5031465756 @default.
• W2013928330 creator A5038194767 @default.
• W2013928330 creator A5064559752 @default.
• W2013928330 date "2001-08-01" @default.
• W2013928330 modified "2023-09-25" @default.
• W2013928330 title "Antibody-Secreting Cell Responses to Rotavirus Proteins in Gnotobiotic Pigs Inoculated with Attenuated or Virulent Human Rotavirus" @default.
• W2013928330 cites W1507981635 @default.
• W2013928330 cites W1522005625 @default.
• W2013928330 cites W1524951584 @default.
• W2013928330 cites W1640432930 @default.
• W2013928330 cites W1757669931 @default.
• W2013928330 cites W1765894154 @default.
• W2013928330 cites W1775925147 @default.
• W2013928330 cites W1909241563 @default.
• W2013928330 cites W1964993389 @default.
• W2013928330 cites W1988939670 @default.
• W2013928330 cites W1990876250 @default.
• W2013928330 cites W2004421522 @default.
• W2013928330 cites W2009698439 @default.
• W2013928330 cites W2013494959 @default.
• W2013928330 cites W2063075594 @default.
• W2013928330 cites W2070886908 @default.
• W2013928330 cites W2073507900 @default.
• W2013928330 cites W2076200979 @default.
• W2013928330 cites W2085819683 @default.
• W2013928330 cites W2091553021 @default.
• W2013928330 cites W2092449553 @default.
• W2013928330 cites W2104916126 @default.
• W2013928330 cites W2132241785 @default.
• W2013928330 cites W2132924370 @default.
• W2013928330 cites W2135251786 @default.
• W2013928330 cites W2153949562 @default.
• W2013928330 cites W2160321777 @default.
• W2013928330 cites W2160853816 @default.
• W2013928330 cites W2309047693 @default.
• W2013928330 cites W2328274480 @default.
• W2013928330 cites W2395865966 @default.
• W2013928330 cites W4254442253 @default.
• W2013928330 cites W4299587722 @default.
• W2013928330 cites W74387004 @default.
• W2013928330 cites W79169169 @default.
• W2013928330 doi "https://doi.org/10.1128/jcm.39.8.2807-2813.2001" @default.
• W2013928330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/88243" @default.
• W2013928330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11473996" @default.
• W2013928330 hasPublicationYear "2001" @default.
• W2013928330 type Work @default.
• W2013928330 sameAs 2013928330 @default.
• W2013928330 citedByCount "19" @default.
• W2013928330 countsByYear W20139283302013 @default.
• W2013928330 countsByYear W20139283302016 @default.
• W2013928330 countsByYear W20139283302017 @default.
• W2013928330 countsByYear W20139283302019 @default.
• W2013928330 countsByYear W20139283302022 @default.
• W2013928330 crossrefType "journal-article" @default.
• W2013928330 hasAuthorship W2013928330A5021738815 @default.
• W2013928330 hasAuthorship W2013928330A5029022788 @default.
• W2013928330 hasAuthorship W2013928330A5031465756 @default.
• W2013928330 hasAuthorship W2013928330A5038194767 @default.
• W2013928330 hasAuthorship W2013928330A5064559752 @default.
• W2013928330 hasBestOaLocation W20139283301 @default.
• W2013928330 hasConcept C104317684 @default.
• W2013928330 hasConcept C159047783 @default.
• W2013928330 hasConcept C159654299 @default.
• W2013928330 hasConcept C180032290 @default.
• W2013928330 hasConcept C203014093 @default.
• W2013928330 hasConcept C2522874641 @default.
• W2013928330 hasConcept C2776090121 @default.
• W2013928330 hasConcept C2777991845 @default.
• W2013928330 hasConcept C2779053233 @default.
• W2013928330 hasConcept C2779416561 @default.
• W2013928330 hasConcept C2781367151 @default.
• W2013928330 hasConcept C542903549 @default.
• W2013928330 hasConcept C55493867 @default.
• W2013928330 hasConcept C60987743 @default.
• W2013928330 hasConcept C86803240 @default.
• W2013928330 hasConcept C8891405 @default.
• W2013928330 hasConcept C89423630 @default.
• W2013928330 hasConceptScore W2013928330C104317684 @default.
• W2013928330 hasConceptScore W2013928330C159047783 @default.
• W2013928330 hasConceptScore W2013928330C159654299 @default.
• W2013928330 hasConceptScore W2013928330C180032290 @default.
• W2013928330 hasConceptScore W2013928330C203014093 @default.
• W2013928330 hasConceptScore W2013928330C2522874641 @default.
• W2013928330 hasConceptScore W2013928330C2776090121 @default.
• W2013928330 hasConceptScore W2013928330C2777991845 @default.
• W2013928330 hasConceptScore W2013928330C2779053233 @default.
• W2013928330 hasConceptScore W2013928330C2779416561 @default.
• W2013928330 hasConceptScore W2013928330C2781367151 @default.
• W2013928330 hasConceptScore W2013928330C542903549 @default.
• W2013928330 hasConceptScore W2013928330C55493867 @default.
• W2013928330 hasConceptScore W2013928330C60987743 @default.
• W2013928330 hasConceptScore W2013928330C86803240 @default.
• W2013928330 hasConceptScore W2013928330C8891405 @default.
• W2013928330 hasConceptScore W2013928330C89423630 @default.

• next