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- W2013929398 abstract "Heavy (H) chain binding protein (BiP), which binds to free immunoglobulin H chain of the mu and gamma classes, can be demonstrated in pre-B-cells. It is proposed that the displacement of BiP from H chain by light (L) chain terminates the activity of the enzyme system, L-generase, which catalyzes DNA rearrangement at the L chain loci, generating the complete gene which may or may not be functional. This ensures allelic and isotypic exclusion for the L chain loci. It is further proposed that those cells that productively rearrange both alleles at the H chain locus are eliminated by the H chain toxicity effect." @default.
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- W2013929398 title "A theory of allelic and isotypic exclusion for immunoglobulin genes." @default.
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- W2013929398 doi "https://doi.org/10.1073/pnas.79.22.6976" @default.
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