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- W2013939111 abstract "On behalf of Roche, I write to address inaccuracies in the Editorial in your September issue. 1 The Lancet OncologyPatient priority in the era of patent expiries. Lancet Oncol. 2014; 15: 1039 Summary Full Text Full Text PDF PubMed Scopus (1) Google Scholar In particular, I would like to draw attention to three areas that are inaccurately described: the suggestion that Roche attempted a takeover bid for AstraZenca; the implication that research and development (R&D) investment is in decline at Roche; and the statement that there is a lack of evidence of greater efficacy of ado-trastuzumab emtansine (T-DM1) in head-to-head comparison with trastuzumab. Patient priority in the era of patent expiriesOn Aug 8, 2014, the UK National Institute for Health and Care Excellence (NICE) ruled that trastuzumab emtansine is not cost effective for routine use for patients with HER2-positive breast cancer in England's National Health Service. Trastuzumab emtansine is an antibody–drug conjugate consisting of the previously marketed trastuzumab linked to the cytotoxic agent maytansine. Using clinical data from the EMILIA and TH3RESA trials, Roche valued the drug at just over £90 000 per patient—more than twice the price of trastuzumab alone—despite a lack of head-to-head evidence showing trastuzumab emtansine's greater efficacy compared with trastuzumab to justify the higher price. Full-Text PDF" @default.
- W2013939111 created "2016-06-24" @default.
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- W2013939111 date "2014-10-01" @default.
- W2013939111 modified "2023-10-14" @default.
- W2013939111 title "Patient priority in the era of patent expiries" @default.
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- W2013939111 doi "https://doi.org/10.1016/s1470-2045(14)70470-x" @default.
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