Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013940704> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2013940704 abstract "Individuals with Down syndrome (DS; trisomy 21) are at increased risk for Alzheimer's disease (AD) and they develop amyloid beta plaques (Aβ) by 30 years because they have 3 copies of the gene encoding amyloid precursor protein (APP). Therefore, they are an ideal population in which to validate Aβ biomarkers. Currently, brain levels of Aβ are measured invasively via lumbar puncture or radioactive ligand-based positron emission tomography. Non-invasive biomarkers are necessary for early screening and repeatability. Non-invasive T1-rho-weighted magnetic resonance imaging (T1ρ MRI) detects Aβ in transgenic mouse models of AD and shows decreases at plaque deposition; we are investigating its use as an early biomarker of Aβ in DS subjects. The current sample includes 9 DS subjects (ages 36–54) compared to 9 subjects (ages 54–89) with normal cognition (NC). T1ρ dispersion curves were quantified in AD-related regions of interest (ROIs) delineated using FreeSurfer. The dispersion curves include quantified T1, T2, and two T1ρ values (at FSL=275 and 550 Hz). Curve features between DS and NC were compared and APOE status and family history of AD will be incorporated into analyses. DS subjects showed a lower slope between the two T1rho data points compared to NC subjects in a priori ROIs, including the left amygdala (p=.005), left temporal pole (p=.013), right isthmus of the cingulate gyrus (p=.029), and right parahippocampal gyrus (p=.012). The contralateral temporal pole and isthmus of the cingulate trended in the same direction but did not reach significance. Preliminary analysis suggests APOE status and family history modulate the relationship between diagnostic category and T1ρ." @default.
- W2013940704 created "2016-06-24" @default.
- W2013940704 creator A5009545818 @default.
- W2013940704 creator A5016773409 @default.
- W2013940704 creator A5033855899 @default.
- W2013940704 creator A5040669389 @default.
- W2013940704 creator A5041687327 @default.
- W2013940704 creator A5061641139 @default.
- W2013940704 creator A5079218502 @default.
- W2013940704 date "2013-07-01" @default.
- W2013940704 modified "2023-09-27" @default.
- W2013940704 title "IC-P-146: Amyloid burden measured by T1-rho-weighted MRI in Down syndrome" @default.
- W2013940704 doi "https://doi.org/10.1016/j.jalz.2013.05.143" @default.
- W2013940704 hasPublicationYear "2013" @default.
- W2013940704 type Work @default.
- W2013940704 sameAs 2013940704 @default.
- W2013940704 citedByCount "0" @default.
- W2013940704 crossrefType "journal-article" @default.
- W2013940704 hasAuthorship W2013940704A5009545818 @default.
- W2013940704 hasAuthorship W2013940704A5016773409 @default.
- W2013940704 hasAuthorship W2013940704A5033855899 @default.
- W2013940704 hasAuthorship W2013940704A5040669389 @default.
- W2013940704 hasAuthorship W2013940704A5041687327 @default.
- W2013940704 hasAuthorship W2013940704A5061641139 @default.
- W2013940704 hasAuthorship W2013940704A5079218502 @default.
- W2013940704 hasConcept C118552586 @default.
- W2013940704 hasConcept C126322002 @default.
- W2013940704 hasConcept C126838900 @default.
- W2013940704 hasConcept C142724271 @default.
- W2013940704 hasConcept C143409427 @default.
- W2013940704 hasConcept C2775842073 @default.
- W2013940704 hasConcept C2778048536 @default.
- W2013940704 hasConcept C2778186239 @default.
- W2013940704 hasConcept C2778733324 @default.
- W2013940704 hasConcept C2779226451 @default.
- W2013940704 hasConcept C2779369059 @default.
- W2013940704 hasConcept C2779954681 @default.
- W2013940704 hasConcept C2781099131 @default.
- W2013940704 hasConcept C2781197716 @default.
- W2013940704 hasConcept C2989005 @default.
- W2013940704 hasConcept C54355233 @default.
- W2013940704 hasConcept C58693492 @default.
- W2013940704 hasConcept C71924100 @default.
- W2013940704 hasConcept C86803240 @default.
- W2013940704 hasConceptScore W2013940704C118552586 @default.
- W2013940704 hasConceptScore W2013940704C126322002 @default.
- W2013940704 hasConceptScore W2013940704C126838900 @default.
- W2013940704 hasConceptScore W2013940704C142724271 @default.
- W2013940704 hasConceptScore W2013940704C143409427 @default.
- W2013940704 hasConceptScore W2013940704C2775842073 @default.
- W2013940704 hasConceptScore W2013940704C2778048536 @default.
- W2013940704 hasConceptScore W2013940704C2778186239 @default.
- W2013940704 hasConceptScore W2013940704C2778733324 @default.
- W2013940704 hasConceptScore W2013940704C2779226451 @default.
- W2013940704 hasConceptScore W2013940704C2779369059 @default.
- W2013940704 hasConceptScore W2013940704C2779954681 @default.
- W2013940704 hasConceptScore W2013940704C2781099131 @default.
- W2013940704 hasConceptScore W2013940704C2781197716 @default.
- W2013940704 hasConceptScore W2013940704C2989005 @default.
- W2013940704 hasConceptScore W2013940704C54355233 @default.
- W2013940704 hasConceptScore W2013940704C58693492 @default.
- W2013940704 hasConceptScore W2013940704C71924100 @default.
- W2013940704 hasConceptScore W2013940704C86803240 @default.
- W2013940704 hasIssue "4S_Part_2" @default.
- W2013940704 hasLocation W20139407041 @default.
- W2013940704 hasOpenAccess W2013940704 @default.
- W2013940704 hasPrimaryLocation W20139407041 @default.
- W2013940704 hasRelatedWork W2013940704 @default.
- W2013940704 hasRelatedWork W2021569957 @default.
- W2013940704 hasRelatedWork W2022896865 @default.
- W2013940704 hasRelatedWork W2049232279 @default.
- W2013940704 hasRelatedWork W2146303499 @default.
- W2013940704 hasRelatedWork W2158200838 @default.
- W2013940704 hasRelatedWork W2161096528 @default.
- W2013940704 hasRelatedWork W2586294502 @default.
- W2013940704 hasRelatedWork W2750891463 @default.
- W2013940704 hasRelatedWork W2913624518 @default.
- W2013940704 hasVolume "9" @default.
- W2013940704 isParatext "false" @default.
- W2013940704 isRetracted "false" @default.
- W2013940704 magId "2013940704" @default.
- W2013940704 workType "article" @default.