FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013940956> ?p ?o ?g. }

• W2013940956 endingPage "308" @default.
• W2013940956 startingPage "295" @default.
• W2013940956 abstract "3′-Deoxy-3′-azidothymidine (AZT) has been shown to synergistically inhibit the replication of human immunodeficiency virus type 1 (HIV-1) in cell culture when combined with several other 2′,3′-dideoxynucleoside analogs. In an effort to understand the biochemical mechanism of this synergy, we have examined the effect of combinations of the 5′-triphosphate of AZT (AZT-TP) with either ddCTP, ddATP, or the 5′-triphosphate of the carbocyclic analog of 2′,3′didehydro-2′,3′-dideoxyguanosine (carbovir) on both the RNA-directed and DNA-directed DNA polymerase activity of HIV-1 reverse transcriptase. Kinetic studies, which evaluated the ability of these combinations to competitively inhibit the enzyme, showed that AZT-TP could not bind to the enzyme with either the RNA or DNA template at the same time as either of the other three inhibitors. None of these analogs could affect the incorporation of another analog into the DNA chain by the HIV-1 reverse transcriptase. These results indicated that synergistic inhibition of the HIV-1 reverse transcriptase is not responsible for the synergistic antiviral activity seen in cell culture with combinations of these nucleoside analogs." @default.
• W2013940956 created "2016-06-24" @default.
• W2013940956 creator A5003182481 @default.
• W2013940956 creator A5027623984 @default.
• W2013940956 creator A5047366671 @default.
• W2013940956 creator A5064978721 @default.
• W2013940956 date "1993-12-01" @default.
• W2013940956 modified "2023-09-27" @default.
• W2013940956 title "Lack of synergy in the inhibition of HIV-1 reverse transcriptase by combinations of the 5′-triphosphates of various anti-HIV nucleoside analogs" @default.
• W2013940956 cites W1480548185 @default.
• W2013940956 cites W1489810714 @default.
• W2013940956 cites W1503777058 @default.
• W2013940956 cites W1586361638 @default.
• W2013940956 cites W1976580962 @default.
• W2013940956 cites W1980924297 @default.
• W2013940956 cites W1989692384 @default.
• W2013940956 cites W1998822691 @default.
• W2013940956 cites W2003903604 @default.
• W2013940956 cites W2015194503 @default.
• W2013940956 cites W2020210758 @default.
• W2013940956 cites W2029581385 @default.
• W2013940956 cites W2030236062 @default.
• W2013940956 cites W2030484172 @default.
• W2013940956 cites W2036539609 @default.
• W2013940956 cites W2053183089 @default.
• W2013940956 cites W2056862286 @default.
• W2013940956 cites W2072409481 @default.
• W2013940956 cites W2091343835 @default.
• W2013940956 cites W2093357483 @default.
• W2013940956 cites W2102973576 @default.
• W2013940956 cites W2125344913 @default.
• W2013940956 cites W2143788821 @default.
• W2013940956 cites W2147184898 @default.
• W2013940956 cites W2163782658 @default.
• W2013940956 cites W2173733293 @default.
• W2013940956 cites W2478820410 @default.
• W2013940956 cites W4237110073 @default.
• W2013940956 doi "https://doi.org/10.1016/0166-3542(93)90039-l" @default.
• W2013940956 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7506513" @default.
• W2013940956 hasPublicationYear "1993" @default.
• W2013940956 type Work @default.
• W2013940956 sameAs 2013940956 @default.
• W2013940956 citedByCount "27" @default.
• W2013940956 crossrefType "journal-article" @default.
• W2013940956 hasAuthorship W2013940956A5003182481 @default.
• W2013940956 hasAuthorship W2013940956A5027623984 @default.
• W2013940956 hasAuthorship W2013940956A5047366671 @default.
• W2013940956 hasAuthorship W2013940956A5064978721 @default.
• W2013940956 hasConcept C104317684 @default.
• W2013940956 hasConcept C153574943 @default.
• W2013940956 hasConcept C153911025 @default.
• W2013940956 hasConcept C156719811 @default.
• W2013940956 hasConcept C159047783 @default.
• W2013940956 hasConcept C181199279 @default.
• W2013940956 hasConcept C2522874641 @default.
• W2013940956 hasConcept C2756471 @default.
• W2013940956 hasConcept C2776352584 @default.
• W2013940956 hasConcept C2776543447 @default.
• W2013940956 hasConcept C2777333352 @default.
• W2013940956 hasConcept C2777351918 @default.
• W2013940956 hasConcept C2780216070 @default.
• W2013940956 hasConcept C2780727368 @default.
• W2013940956 hasConcept C2909970146 @default.
• W2013940956 hasConcept C2910803801 @default.
• W2013940956 hasConcept C512185932 @default.
• W2013940956 hasConcept C552990157 @default.
• W2013940956 hasConcept C55493867 @default.
• W2013940956 hasConcept C64241487 @default.
• W2013940956 hasConcept C67705224 @default.
• W2013940956 hasConcept C82381507 @default.
• W2013940956 hasConcept C86803240 @default.
• W2013940956 hasConceptScore W2013940956C104317684 @default.
• W2013940956 hasConceptScore W2013940956C153574943 @default.
• W2013940956 hasConceptScore W2013940956C153911025 @default.
• W2013940956 hasConceptScore W2013940956C156719811 @default.
• W2013940956 hasConceptScore W2013940956C159047783 @default.
• W2013940956 hasConceptScore W2013940956C181199279 @default.
• W2013940956 hasConceptScore W2013940956C2522874641 @default.
• W2013940956 hasConceptScore W2013940956C2756471 @default.
• W2013940956 hasConceptScore W2013940956C2776352584 @default.
• W2013940956 hasConceptScore W2013940956C2776543447 @default.
• W2013940956 hasConceptScore W2013940956C2777333352 @default.
• W2013940956 hasConceptScore W2013940956C2777351918 @default.
• W2013940956 hasConceptScore W2013940956C2780216070 @default.
• W2013940956 hasConceptScore W2013940956C2780727368 @default.
• W2013940956 hasConceptScore W2013940956C2909970146 @default.
• W2013940956 hasConceptScore W2013940956C2910803801 @default.
• W2013940956 hasConceptScore W2013940956C512185932 @default.
• W2013940956 hasConceptScore W2013940956C552990157 @default.
• W2013940956 hasConceptScore W2013940956C55493867 @default.
• W2013940956 hasConceptScore W2013940956C64241487 @default.
• W2013940956 hasConceptScore W2013940956C67705224 @default.
• W2013940956 hasConceptScore W2013940956C82381507 @default.
• W2013940956 hasConceptScore W2013940956C86803240 @default.
• W2013940956 hasIssue "4" @default.
• W2013940956 hasLocation W20139409561 @default.
• W2013940956 hasLocation W20139409562 @default.
• W2013940956 hasOpenAccess W2013940956 @default.

• next