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- W2013944203 abstract "<h2>Abstract</h2> A detailed analysis has been carried out of tumor cure doses for three fractions per week X-ray treatments of an experimental rhabdomyosarcoma in rats. The tumor cure doses rise sharply between 1 and 5 days, have a slight dip at 10 days, and then rise steadily from 10 to 50 days. The 10–50 day portion of the time-dose relationship appears to be linear when plotted on a linear coordinate plot of tumor cure dose versus time; the time-dose relationship is not linear when plotted on log-log coordinates. Because a constant number of fractions/week were used in all fractionation schemes, the relative importance of time and fraction number could not be assessed directly. An analysis of the tumor cure time-dose relationship and the known <i>in vivo</i> and <i>in vitro</i> characteristics of the tumor cells suggests that there is effective reoxygenation in fractionation schemes longer than 10 days, and that repair of sublethal damage is a more important factor in the increases of the tumor cure dose with fractionation than is repopulation between treatments. A comparison of these tumor cure time-dose relationships with previously published normal tissue tolerance time-dose relationships shows that three fraction/week treatments lasting 5–33 days give no better and often worse results than single doses, but that a three fraction/week treatment lasting 50 days gives dramatically better therapeutic results." @default.
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- W2013944203 title "Time-dose relationships for the cure of an experimental rat tumor with fractionated radiation" @default.
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- W2013944203 doi "https://doi.org/10.1016/0360-3016(76)90008-0" @default.
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