Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013961818> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2013961818 endingPage "498" @default.
- W2013961818 startingPage "493" @default.
- W2013961818 abstract "The axonal synthesis of phospholipids has been demonstrated in compartmented cultures of rat sympathetic neurons. In this model of neuron culture, metabolic events occurring in distal axons were studied independently of those occurring in cell bodies. Using radiolabeled tracers the axonal biosynthesis of the major membrane phospholipids and fatty acids but not cholesterol was detected. The capacity of axons for synthesis of phosphatidycholine (PC), the major membrane lipid, was confirmed by the demonstration that key enzymes of PC biosynthesis were present in distal axons. A double-labeling experiment showed that at least 50% of axonal PC was synthesized locally in axons, with the remainder being made in cell bodies and transported into axons. The requirement of axonal PC synthesis for axonal elongation was investigated. When PC biosynthesis in distal axons alone was inhibited by two independent approaches (deprivation of choline or addition of the inhibitor hexadecylphosphocholine) axonal growth was markedly retarded. Our experiments demonstrated that PC synthesis in cell bodies was neither necessary nor sufficient for growth of distal axons, whereas local synthesis of PC in distal axons was required for normal axonal elongation." @default.
- W2013961818 created "2016-06-24" @default.
- W2013961818 creator A5019669813 @default.
- W2013961818 creator A5035731864 @default.
- W2013961818 creator A5057746394 @default.
- W2013961818 creator A5073998071 @default.
- W2013961818 date "1995-05-01" @default.
- W2013961818 modified "2023-10-13" @default.
- W2013961818 title "Role of axons in membrane phospholipid synthesis in rat sympathetic neurons" @default.
- W2013961818 cites W1516408301 @default.
- W2013961818 cites W1561474071 @default.
- W2013961818 cites W1565474821 @default.
- W2013961818 cites W1586986973 @default.
- W2013961818 cites W1720974536 @default.
- W2013961818 cites W1909266718 @default.
- W2013961818 cites W1965990791 @default.
- W2013961818 cites W1972706960 @default.
- W2013961818 cites W1979844286 @default.
- W2013961818 cites W1984961720 @default.
- W2013961818 cites W1989517748 @default.
- W2013961818 cites W1994532732 @default.
- W2013961818 cites W2001059958 @default.
- W2013961818 cites W2029410939 @default.
- W2013961818 cites W2033613548 @default.
- W2013961818 cites W2039029470 @default.
- W2013961818 cites W2069134576 @default.
- W2013961818 cites W2098208316 @default.
- W2013961818 cites W2141311887 @default.
- W2013961818 cites W2168526937 @default.
- W2013961818 cites W2170384440 @default.
- W2013961818 cites W3165285855 @default.
- W2013961818 cites W4293247451 @default.
- W2013961818 cites W4299832967 @default.
- W2013961818 doi "https://doi.org/10.1016/0197-4580(94)00180-9" @default.
- W2013961818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7566356" @default.
- W2013961818 hasPublicationYear "1995" @default.
- W2013961818 type Work @default.
- W2013961818 sameAs 2013961818 @default.
- W2013961818 citedByCount "17" @default.
- W2013961818 countsByYear W20139618182015 @default.
- W2013961818 countsByYear W20139618182019 @default.
- W2013961818 countsByYear W20139618182020 @default.
- W2013961818 countsByYear W20139618182021 @default.
- W2013961818 crossrefType "journal-article" @default.
- W2013961818 hasAuthorship W2013961818A5019669813 @default.
- W2013961818 hasAuthorship W2013961818A5035731864 @default.
- W2013961818 hasAuthorship W2013961818A5057746394 @default.
- W2013961818 hasAuthorship W2013961818A5073998071 @default.
- W2013961818 hasConcept C12554922 @default.
- W2013961818 hasConcept C135903288 @default.
- W2013961818 hasConcept C169760540 @default.
- W2013961818 hasConcept C181199279 @default.
- W2013961818 hasConcept C185592680 @default.
- W2013961818 hasConcept C2778794669 @default.
- W2013961818 hasConcept C2778918659 @default.
- W2013961818 hasConcept C2779530196 @default.
- W2013961818 hasConcept C41625074 @default.
- W2013961818 hasConcept C553450214 @default.
- W2013961818 hasConcept C55493867 @default.
- W2013961818 hasConcept C70192387 @default.
- W2013961818 hasConcept C86803240 @default.
- W2013961818 hasConcept C95444343 @default.
- W2013961818 hasConceptScore W2013961818C12554922 @default.
- W2013961818 hasConceptScore W2013961818C135903288 @default.
- W2013961818 hasConceptScore W2013961818C169760540 @default.
- W2013961818 hasConceptScore W2013961818C181199279 @default.
- W2013961818 hasConceptScore W2013961818C185592680 @default.
- W2013961818 hasConceptScore W2013961818C2778794669 @default.
- W2013961818 hasConceptScore W2013961818C2778918659 @default.
- W2013961818 hasConceptScore W2013961818C2779530196 @default.
- W2013961818 hasConceptScore W2013961818C41625074 @default.
- W2013961818 hasConceptScore W2013961818C553450214 @default.
- W2013961818 hasConceptScore W2013961818C55493867 @default.
- W2013961818 hasConceptScore W2013961818C70192387 @default.
- W2013961818 hasConceptScore W2013961818C86803240 @default.
- W2013961818 hasConceptScore W2013961818C95444343 @default.
- W2013961818 hasIssue "3" @default.
- W2013961818 hasLocation W20139618181 @default.
- W2013961818 hasLocation W20139618182 @default.
- W2013961818 hasOpenAccess W2013961818 @default.
- W2013961818 hasPrimaryLocation W20139618181 @default.
- W2013961818 hasRelatedWork W1966663931 @default.
- W2013961818 hasRelatedWork W1977054468 @default.
- W2013961818 hasRelatedWork W2026780867 @default.
- W2013961818 hasRelatedWork W2038850809 @default.
- W2013961818 hasRelatedWork W2081159655 @default.
- W2013961818 hasRelatedWork W2765090685 @default.
- W2013961818 hasRelatedWork W2894917276 @default.
- W2013961818 hasRelatedWork W4234652017 @default.
- W2013961818 hasRelatedWork W4283205121 @default.
- W2013961818 hasRelatedWork W4321002291 @default.
- W2013961818 hasVolume "16" @default.
- W2013961818 isParatext "false" @default.
- W2013961818 isRetracted "false" @default.
- W2013961818 magId "2013961818" @default.
- W2013961818 workType "article" @default.