FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013961837> ?p ?o ?g. }

• W2013961837 endingPage "267" @default.
• W2013961837 startingPage "261" @default.
• W2013961837 abstract "In a Guidance document, the American FDA recommends the use of a Minolta chromameter rather than the human eye for the quantitative assessment of the pharmacodynamic blanching response produced by topical application of corticosteroids. The purpose of this study was to compare the appropriateness of the human eye and two models of chromameter for the estimation of skin blanching, in terms of the quality of the data generated by each method. The corticosteroid-induced skin blanching from four different betamethasone 17-valerate cream formulations was compared in a typical human skin blanching trial. The optimized assay methodology routinely practised in our laboratories was utilized. The blanching responses were assessed visually by three trained, independent observers and recorded by two chromameters (Minolta model CR-200 and model CR-300). The topical availability of the four creams was determined using visual scoring and chromameter measurements. All data were manipulated in such a manner as to produce a blanching response versus time profile from which AUBC analysis could be performed. Good correlation was observed between the visual assessments made by three independent observers. In contrast, moderate correlation was determined between visual, CR-200 and CR-300 measurements. Surprisingly, no direct linear relationship between the AUBCs produced by the two chromameters was observed indicating that the quality of the data obtained from the two instruments may not be equal. This investigation also indicated that the use of the chromameter is not completely objective. Visual scoring and chromameter measurement produce data sets that differ in quality. Each procedure needs to be validated and investigators have to be trained for both visual assessment and the operation of the chromameter, particularly with regard to the manipulation of the measuring head of the instrument." @default.
• W2013961837 created "2016-06-24" @default.
• W2013961837 creator A5029188927 @default.
• W2013961837 creator A5060646904 @default.
• W2013961837 creator A5064367602 @default.
• W2013961837 creator A5082116524 @default.
• W2013961837 date "1999-05-01" @default.
• W2013961837 modified "2023-10-16" @default.
• W2013961837 title "Analysis of chromameter results obtained from corticosteroid-induced skin blanching assay: comparison of visual and chromameter data" @default.
• W2013961837 cites W1487549981 @default.
• W2013961837 cites W1514111872 @default.
• W2013961837 cites W2007265951 @default.
• W2013961837 cites W2029749394 @default.
• W2013961837 cites W203370318 @default.
• W2013961837 cites W2074042272 @default.
• W2013961837 cites W2076847565 @default.
• W2013961837 cites W2110525034 @default.
• W2013961837 cites W2132176181 @default.
• W2013961837 cites W2132388437 @default.
• W2013961837 cites W2134622679 @default.
• W2013961837 cites W2280903090 @default.
• W2013961837 cites W4242871825 @default.
• W2013961837 doi "https://doi.org/10.1016/s0939-6411(98)00094-0" @default.
• W2013961837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10382110" @default.
• W2013961837 hasPublicationYear "1999" @default.
• W2013961837 type Work @default.
• W2013961837 sameAs 2013961837 @default.
• W2013961837 citedByCount "15" @default.
• W2013961837 countsByYear W20139618372012 @default.
• W2013961837 countsByYear W20139618372013 @default.
• W2013961837 countsByYear W20139618372014 @default.
• W2013961837 countsByYear W20139618372016 @default.
• W2013961837 countsByYear W20139618372017 @default.
• W2013961837 crossrefType "journal-article" @default.
• W2013961837 hasAuthorship W2013961837A5029188927 @default.
• W2013961837 hasAuthorship W2013961837A5060646904 @default.
• W2013961837 hasAuthorship W2013961837A5064367602 @default.
• W2013961837 hasAuthorship W2013961837A5082116524 @default.
• W2013961837 hasConcept C185592680 @default.
• W2013961837 hasConcept C2776265840 @default.
• W2013961837 hasConcept C31903555 @default.
• W2013961837 hasConcept C33923547 @default.
• W2013961837 hasConcept C71924100 @default.
• W2013961837 hasConceptScore W2013961837C185592680 @default.
• W2013961837 hasConceptScore W2013961837C2776265840 @default.
• W2013961837 hasConceptScore W2013961837C31903555 @default.
• W2013961837 hasConceptScore W2013961837C33923547 @default.
• W2013961837 hasConceptScore W2013961837C71924100 @default.
• W2013961837 hasIssue "3" @default.
• W2013961837 hasLocation W20139618371 @default.
• W2013961837 hasLocation W20139618372 @default.
• W2013961837 hasOpenAccess W2013961837 @default.
• W2013961837 hasPrimaryLocation W20139618371 @default.
• W2013961837 hasRelatedWork W1995515455 @default.
• W2013961837 hasRelatedWork W2038661747 @default.
• W2013961837 hasRelatedWork W2080531066 @default.
• W2013961837 hasRelatedWork W2171109215 @default.
• W2013961837 hasRelatedWork W2362307039 @default.
• W2013961837 hasRelatedWork W2748952813 @default.
• W2013961837 hasRelatedWork W2899084033 @default.
• W2013961837 hasRelatedWork W3031052312 @default.
• W2013961837 hasRelatedWork W3032375762 @default.
• W2013961837 hasRelatedWork W4360977454 @default.
• W2013961837 hasVolume "47" @default.
• W2013961837 isParatext "false" @default.
• W2013961837 isRetracted "false" @default.
• W2013961837 magId "2013961837" @default.
• W2013961837 workType "article" @default.