Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013963125> ?p ?o ?g. }
- W2013963125 endingPage "286" @default.
- W2013963125 startingPage "286" @default.
- W2013963125 abstract "Cytochrome P450 (CYP) enzymatic activity, which is influenced by CYP genetic polymorphism, is known to affect the inter-individual variation in the efficacy and tolerability of antidepressants in major depressive disorder (MDD). Escitalopram is metabolized by CYP2D6, and recent studies have reported a correlation between clinical outcomes and CYP2D6 genetic polymorphism. The purpose of this study was to determine the relationship between the CYP2D6 P34S polymorphism (C188T, rs1065852) and the efficacy of escitalopram treatment in Korean patients with MDD.A total of 94 patients diagnosed with MDD were recruited for the study and their symptoms were evaluated using the 21-item Hamilton Depression Rating scale (HAMD-21). The association between the CYP2D6 P34S polymorphism and the clinical outcomes (remission and response) was investigated after 1, 2, 4, 8, and 12 weeks of escitalopram treatment using multiple logistic regression analysis and χ(2) test.The proportion of P allele carriers (PP, PS) in remission status was greater than that of S allele homozygotes (SS) after 8 and 12 weeks of escitalopram treatment. Similarly, P allele carriers exhibited a greater treatment response after 8 and 12 weeks of escitalopram treatment than S allele homozygotes.Our results suggest that the P allele of the CYP2D6 P34S polymorphism is a favorable factor in escitalopram treatment for MDD, and that the CYP2D6 P34S polymorphism may be a good genetic marker for predicting escitalopram treatment outcomes." @default.
- W2013963125 created "2016-06-24" @default.
- W2013963125 creator A5025431419 @default.
- W2013963125 creator A5047917981 @default.
- W2013963125 creator A5066772914 @default.
- W2013963125 creator A5070647938 @default.
- W2013963125 creator A5080377887 @default.
- W2013963125 date "2013-01-01" @default.
- W2013963125 modified "2023-10-02" @default.
- W2013963125 title "CYP2D6 P34S Polymorphism and Outcomes of Escitalopram Treatment in Koreans with Major Depression" @default.
- W2013963125 cites W1766115599 @default.
- W2013963125 cites W1772928229 @default.
- W2013963125 cites W1967378279 @default.
- W2013963125 cites W1981896133 @default.
- W2013963125 cites W1984131408 @default.
- W2013963125 cites W1986761759 @default.
- W2013963125 cites W1992264046 @default.
- W2013963125 cites W1993067969 @default.
- W2013963125 cites W1998437481 @default.
- W2013963125 cites W2002050650 @default.
- W2013963125 cites W2007781929 @default.
- W2013963125 cites W2007898753 @default.
- W2013963125 cites W2009132689 @default.
- W2013963125 cites W2014851780 @default.
- W2013963125 cites W2017191415 @default.
- W2013963125 cites W2032149427 @default.
- W2013963125 cites W2032996390 @default.
- W2013963125 cites W2037879812 @default.
- W2013963125 cites W2038188157 @default.
- W2013963125 cites W2052090143 @default.
- W2013963125 cites W2054739757 @default.
- W2013963125 cites W2062935033 @default.
- W2013963125 cites W2065054645 @default.
- W2013963125 cites W2074460311 @default.
- W2013963125 cites W2085725490 @default.
- W2013963125 cites W2087215222 @default.
- W2013963125 cites W2095575057 @default.
- W2013963125 cites W2095623768 @default.
- W2013963125 cites W2098988764 @default.
- W2013963125 cites W2124470239 @default.
- W2013963125 cites W2124700493 @default.
- W2013963125 cites W2136825478 @default.
- W2013963125 cites W2138246979 @default.
- W2013963125 cites W2146103479 @default.
- W2013963125 cites W2150274550 @default.
- W2013963125 cites W2152797524 @default.
- W2013963125 cites W2155724210 @default.
- W2013963125 cites W4211085917 @default.
- W2013963125 cites W4301006693 @default.
- W2013963125 cites W80052973 @default.
- W2013963125 doi "https://doi.org/10.4306/pi.2013.10.3.286" @default.
- W2013963125 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3843022" @default.
- W2013963125 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24302953" @default.
- W2013963125 hasPublicationYear "2013" @default.
- W2013963125 type Work @default.
- W2013963125 sameAs 2013963125 @default.
- W2013963125 citedByCount "15" @default.
- W2013963125 countsByYear W20139631252014 @default.
- W2013963125 countsByYear W20139631252015 @default.
- W2013963125 countsByYear W20139631252017 @default.
- W2013963125 countsByYear W20139631252018 @default.
- W2013963125 countsByYear W20139631252019 @default.
- W2013963125 countsByYear W20139631252020 @default.
- W2013963125 countsByYear W20139631252021 @default.
- W2013963125 countsByYear W20139631252023 @default.
- W2013963125 crossrefType "journal-article" @default.
- W2013963125 hasAuthorship W2013963125A5025431419 @default.
- W2013963125 hasAuthorship W2013963125A5047917981 @default.
- W2013963125 hasAuthorship W2013963125A5066772914 @default.
- W2013963125 hasAuthorship W2013963125A5070647938 @default.
- W2013963125 hasAuthorship W2013963125A5080377887 @default.
- W2013963125 hasBestOaLocation W20139631251 @default.
- W2013963125 hasConcept C104317684 @default.
- W2013963125 hasConcept C118552586 @default.
- W2013963125 hasConcept C126322002 @default.
- W2013963125 hasConcept C135763542 @default.
- W2013963125 hasConcept C139719470 @default.
- W2013963125 hasConcept C143998085 @default.
- W2013963125 hasConcept C149737253 @default.
- W2013963125 hasConcept C151956035 @default.
- W2013963125 hasConcept C15744967 @default.
- W2013963125 hasConcept C162324750 @default.
- W2013963125 hasConcept C180754005 @default.
- W2013963125 hasConcept C197934379 @default.
- W2013963125 hasConcept C2776466505 @default.
- W2013963125 hasConcept C2776867660 @default.
- W2013963125 hasConcept C2778375690 @default.
- W2013963125 hasConcept C2779144063 @default.
- W2013963125 hasConcept C2779177272 @default.
- W2013963125 hasConcept C2779583969 @default.
- W2013963125 hasConcept C2780051608 @default.
- W2013963125 hasConcept C2781161787 @default.
- W2013963125 hasConcept C33664856 @default.
- W2013963125 hasConcept C526171541 @default.
- W2013963125 hasConcept C54355233 @default.
- W2013963125 hasConcept C55775858 @default.
- W2013963125 hasConcept C62231903 @default.
- W2013963125 hasConcept C71924100 @default.