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- W2013965608 abstract "Abstract 1. 1. The uptake of arabinosyl-6-mercaptopurine was studied in vitro in L1210 cells and in an arabinosyl-6-mercaptopurine-resistant subline. There was little or no difference in the rate of uptake, Km and V values between the two cell lines. This strengthens the conclusion that the arabinosyl-6-mercaptopurine-resistant subline of L1210 cells is due to an insensitive ribonucleotide reductase and not due to an impairment in the capacity for arabinosyl-6-mercaptopurine accumulation. 2. 2. A new technique is described for the rapid separation of cells from the reaction medium by centrifugation through silicone oil. This permitted the measurement of actual rates of antimetabolite or nucleoside movement in cells. 3. 3. The water-permeable space was estimated to be 208 μl per 109 cells, since there was little or no detectable [carboxyl-14C]inulin in the cell pellet." @default.
- W2013965608 created "2016-06-24" @default.
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- W2013965608 date "1972-06-01" @default.
- W2013965608 modified "2023-09-27" @default.
- W2013965608 title "The determination of the uptake of arabinosyl-6-mercaptopurine by L1210 cells" @default.
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- W2013965608 doi "https://doi.org/10.1016/0005-2736(72)90369-0" @default.
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