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- W2013965621 abstract "Concentrations of 6-oxo-prostaglandin F1α (6-oxo-PGF1α), the stable hydrolysis product of prostacyclin (PGI2) were determined in venous blood sampled from a forearm vein after dextrose (10% w/v) perfusion and after subsequent distension with physiological saline in seven healthy volunteers. 6-oxo-PGF1α was measured by gas chromatography/negative ion chemical ionisation mass spectrometry. Local release of PGI2 was demonstrated in six volunteers: in three both stimuli were effective and in three only one stimulus was effective. In seven trained athletes studied before and after vigorous exercise baseline plasma concentrations of 6-oxo-PGF1α were <1·3-3·2 pg/ml. The concentration increased after exercise in each subject (mean 10·9 pg/ml; range 5·5-18·2 pg/ml). Mild chemical and mechanical stimuli therefore can cause local production of PGI2 from human blood vessels in vivo." @default.
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- W2013965621 date "1982-03-01" @default.
- W2013965621 modified "2023-09-27" @default.
- W2013965621 title "The time course and magnitude of prostacyclin (PGI2) production by rat aortic rings incubated in human plasma" @default.
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- W2013965621 doi "https://doi.org/10.1016/0006-2952(82)90361-6" @default.
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