Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013969500> ?p ?o ?g. }
- W2013969500 endingPage "241" @default.
- W2013969500 startingPage "233" @default.
- W2013969500 abstract "Poly(ADP‐ribose) polymerase‐1 (PARP‐1) is an abundant nuclear protein best known to facilitate DNA base excision repair. Recent work has expanded the physiologic functions of PARP‐1, and it is clear that the full range of biologic actions of this important protein are not yet fully understood. Regulation of the product of PARP‐1, poly(ADP‐ribose) (PAR), is a dynamic process with PAR glycohydrolase playing the major role in the degradation of the polymer. Under pathophysiologic situations overactivation of PARP‐1 results in unregulated PAR synthesis and widespread neuronal cell death. Once thought to be necrotic cell death resulting from energy failure, we have found that PARP‐1‐dependent cell death is dependent on the generation of PAR, which triggers the nuclear translocation of apoptosis‐inducing factor resulting in caspase‐independent cell death. This form of cell death is distinct from apoptosis, necrosis, or autophagy and is termed parthanatos . PARP‐1‐dependent cell death has been implicated in tissues throughout the body and in diseases afflicting hundreds of millions worldwide, including stroke, Parkinson's disease, heart attack, diabetes, and ischemia reperfusion injury in numerous tissues. The breadth of indications for PARP‐1 injury make parthanatos a clinically important form of cell death to understand and control." @default.
- W2013969500 created "2016-06-24" @default.
- W2013969500 creator A5021759485 @default.
- W2013969500 creator A5025568267 @default.
- W2013969500 creator A5052705491 @default.
- W2013969500 date "2008-12-01" @default.
- W2013969500 modified "2023-10-15" @default.
- W2013969500 title "Mitochondrial and Nuclear Cross Talk in Cell Death" @default.
- W2013969500 cites W1967743344 @default.
- W2013969500 cites W1968112618 @default.
- W2013969500 cites W1968458167 @default.
- W2013969500 cites W1971124502 @default.
- W2013969500 cites W1980460135 @default.
- W2013969500 cites W1981421866 @default.
- W2013969500 cites W1985074609 @default.
- W2013969500 cites W1988860478 @default.
- W2013969500 cites W1992565982 @default.
- W2013969500 cites W1993972255 @default.
- W2013969500 cites W1997953313 @default.
- W2013969500 cites W2001746497 @default.
- W2013969500 cites W2004698905 @default.
- W2013969500 cites W2006806309 @default.
- W2013969500 cites W2009979784 @default.
- W2013969500 cites W2014150894 @default.
- W2013969500 cites W2015590649 @default.
- W2013969500 cites W2019240387 @default.
- W2013969500 cites W2022601703 @default.
- W2013969500 cites W2027811710 @default.
- W2013969500 cites W2028689205 @default.
- W2013969500 cites W2032413974 @default.
- W2013969500 cites W2032580133 @default.
- W2013969500 cites W2042584010 @default.
- W2013969500 cites W2045643757 @default.
- W2013969500 cites W2051029351 @default.
- W2013969500 cites W2051439699 @default.
- W2013969500 cites W2057257618 @default.
- W2013969500 cites W2057706543 @default.
- W2013969500 cites W2059397580 @default.
- W2013969500 cites W2061298493 @default.
- W2013969500 cites W2072528578 @default.
- W2013969500 cites W2072554501 @default.
- W2013969500 cites W2074194694 @default.
- W2013969500 cites W2075500995 @default.
- W2013969500 cites W2084060660 @default.
- W2013969500 cites W2087892357 @default.
- W2013969500 cites W2107240332 @default.
- W2013969500 cites W2116176075 @default.
- W2013969500 cites W2118245574 @default.
- W2013969500 cites W2127927388 @default.
- W2013969500 cites W2132606798 @default.
- W2013969500 cites W2138281508 @default.
- W2013969500 cites W2146528609 @default.
- W2013969500 cites W2151861142 @default.
- W2013969500 cites W2156198504 @default.
- W2013969500 cites W2159650080 @default.
- W2013969500 cites W2168208715 @default.
- W2013969500 doi "https://doi.org/10.1196/annals.1427.014" @default.
- W2013969500 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4454457" @default.
- W2013969500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19076445" @default.
- W2013969500 hasPublicationYear "2008" @default.
- W2013969500 type Work @default.
- W2013969500 sameAs 2013969500 @default.
- W2013969500 citedByCount "277" @default.
- W2013969500 countsByYear W20139695002012 @default.
- W2013969500 countsByYear W20139695002013 @default.
- W2013969500 countsByYear W20139695002014 @default.
- W2013969500 countsByYear W20139695002015 @default.
- W2013969500 countsByYear W20139695002016 @default.
- W2013969500 countsByYear W20139695002017 @default.
- W2013969500 countsByYear W20139695002018 @default.
- W2013969500 countsByYear W20139695002019 @default.
- W2013969500 countsByYear W20139695002020 @default.
- W2013969500 countsByYear W20139695002021 @default.
- W2013969500 countsByYear W20139695002022 @default.
- W2013969500 countsByYear W20139695002023 @default.
- W2013969500 crossrefType "journal-article" @default.
- W2013969500 hasAuthorship W2013969500A5021759485 @default.
- W2013969500 hasAuthorship W2013969500A5025568267 @default.
- W2013969500 hasAuthorship W2013969500A5052705491 @default.
- W2013969500 hasBestOaLocation W20139695002 @default.
- W2013969500 hasConcept C134935766 @default.
- W2013969500 hasConcept C143425029 @default.
- W2013969500 hasConcept C172043667 @default.
- W2013969500 hasConcept C182979987 @default.
- W2013969500 hasConcept C190283241 @default.
- W2013969500 hasConcept C203522944 @default.
- W2013969500 hasConcept C28859421 @default.
- W2013969500 hasConcept C31573885 @default.
- W2013969500 hasConcept C54355233 @default.
- W2013969500 hasConcept C552990157 @default.
- W2013969500 hasConcept C82381507 @default.
- W2013969500 hasConcept C86803240 @default.
- W2013969500 hasConcept C95444343 @default.
- W2013969500 hasConcept C98424977 @default.
- W2013969500 hasConceptScore W2013969500C134935766 @default.
- W2013969500 hasConceptScore W2013969500C143425029 @default.
- W2013969500 hasConceptScore W2013969500C172043667 @default.
- W2013969500 hasConceptScore W2013969500C182979987 @default.