FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013972997> ?p ?o ?g. }

• W2013972997 endingPage "537" @default.
• W2013972997 startingPage "526" @default.
• W2013972997 abstract "It has been shown that the inflammatory response and cellular damage after hemorrhagic shock are influenced by resuscitation strategies. Toll-like receptors (TLRs) play an important role in signal transduction in inflammatory conditions. However, alterations in TLR expression following hemorrhagic shock and resuscitation have not been well documented. This study was conducted to measure the impact of different resuscitation strategies on TLR expression and downstream signaling in key organs.Sprague Dawley rats (n=38) were subjected to a severe volume-controlled hemorrhage protocol. After 75 min of shock, they were resuscitated over 45 min as follows: (1) lactated Ringer's (LR, 81 ml/kg), (2) ketone Ringer's (KR, 81 ml/kg), (3) 7.5% hypertonic saline (HTS, 9.7 ml/kg), (4) 6% hetastarch (HEX, 27 ml/kg), (5) pyruvate Ringer's (PR, 81 ml/kg). Sham hemorrhage (NH) and no resuscitation (NR) groups served as controls. The KR and PR solutions were identical to LR except for equimolar substitution of racemic lactate with beta hydroxybutyrate and sodium pyruvate, respectively. At the end of resuscitation, the expression of TLRs (types 1-10), and cytokines (IL-10, IL-1beta and TNF-alpha) were measured in the lung and spleen using RT-PCR. Levels of phosphorylated and total IkB-alpha and NF-kappaB were detected by Western blotting. The systemic and lung protein levels of TNF-alpha were measured using ELISA and immunohistochemistry.Expression of TLRs in the lung was affected more than in the spleen by hemorrhagic shock and resuscitation. In the lung, hemorrhage increased TLR-2, -3 and -6 (but not TLR-4) mRNA expression, with an up-regulation of the ratio of phosphor-NF-kappaBp65 and total NF-kappaBp65, NF-kappaBp65 activation, and enhanced systemic and tissue TNF-alpha protein levels. Post-resuscitation, TLR mRNA profile and subsequent downstream proteins in the lung and spleen were affected by the choice of resuscitation strategy.Hemorrhagic shock activates TLR signaling in lung, but not the spleen, probably through an up-regulation of TLR gene expression, and activation of NF-kappaB pathway. Resuscitation modulates this response in a fluid- and tissue-specific fashion." @default.
• W2013972997 created "2016-06-24" @default.
• W2013972997 creator A5023767569 @default.
• W2013972997 creator A5027596697 @default.
• W2013972997 creator A5032108644 @default.
• W2013972997 creator A5058961918 @default.
• W2013972997 creator A5069898401 @default.
• W2013972997 date "2007-09-01" @default.
• W2013972997 modified "2023-09-27" @default.
• W2013972997 title "Differential effect of resuscitation on Toll-like receptors in a model of hemorrhagic shock without a septic challenge" @default.
• W2013972997 cites W1533387869 @default.
• W2013972997 cites W1591714343 @default.
• W2013972997 cites W1831064357 @default.
• W2013972997 cites W1963802005 @default.
• W2013972997 cites W1971762512 @default.
• W2013972997 cites W1976302471 @default.
• W2013972997 cites W1991731944 @default.
• W2013972997 cites W2002482345 @default.
• W2013972997 cites W2009852383 @default.
• W2013972997 cites W2010472128 @default.
• W2013972997 cites W2016754754 @default.
• W2013972997 cites W2022012496 @default.
• W2013972997 cites W2028372259 @default.
• W2013972997 cites W2031696610 @default.
• W2013972997 cites W2033553205 @default.
• W2013972997 cites W2042363840 @default.
• W2013972997 cites W2046783872 @default.
• W2013972997 cites W2047872412 @default.
• W2013972997 cites W2069642844 @default.
• W2013972997 cites W2075113278 @default.
• W2013972997 cites W2106466284 @default.
• W2013972997 cites W2121683669 @default.
• W2013972997 cites W2130186203 @default.
• W2013972997 cites W2138209933 @default.
• W2013972997 cites W2144726802 @default.
• W2013972997 cites W2145736817 @default.
• W2013972997 cites W2148349695 @default.
• W2013972997 cites W2148471980 @default.
• W2013972997 cites W2169238760 @default.
• W2013972997 cites W2411561484 @default.
• W2013972997 doi "https://doi.org/10.1016/j.resuscitation.2007.01.031" @default.
• W2013972997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17386967" @default.
• W2013972997 hasPublicationYear "2007" @default.
• W2013972997 type Work @default.
• W2013972997 sameAs 2013972997 @default.
• W2013972997 citedByCount "28" @default.
• W2013972997 countsByYear W20139729972012 @default.
• W2013972997 countsByYear W20139729972013 @default.
• W2013972997 countsByYear W20139729972014 @default.
• W2013972997 countsByYear W20139729972015 @default.
• W2013972997 countsByYear W20139729972016 @default.
• W2013972997 countsByYear W20139729972017 @default.
• W2013972997 countsByYear W20139729972018 @default.
• W2013972997 countsByYear W20139729972019 @default.
• W2013972997 countsByYear W20139729972022 @default.
• W2013972997 crossrefType "journal-article" @default.
• W2013972997 hasAuthorship W2013972997A5023767569 @default.
• W2013972997 hasAuthorship W2013972997A5027596697 @default.
• W2013972997 hasAuthorship W2013972997A5032108644 @default.
• W2013972997 hasAuthorship W2013972997A5058961918 @default.
• W2013972997 hasAuthorship W2013972997A5069898401 @default.
• W2013972997 hasConcept C126322002 @default.
• W2013972997 hasConcept C170493617 @default.
• W2013972997 hasConcept C203014093 @default.
• W2013972997 hasConcept C2777714996 @default.
• W2013972997 hasConcept C2778165595 @default.
• W2013972997 hasConcept C2778754761 @default.
• W2013972997 hasConcept C2781300812 @default.
• W2013972997 hasConcept C3017567848 @default.
• W2013972997 hasConcept C42219234 @default.
• W2013972997 hasConcept C71924100 @default.
• W2013972997 hasConcept C98274493 @default.
• W2013972997 hasConceptScore W2013972997C126322002 @default.
• W2013972997 hasConceptScore W2013972997C170493617 @default.
• W2013972997 hasConceptScore W2013972997C203014093 @default.
• W2013972997 hasConceptScore W2013972997C2777714996 @default.
• W2013972997 hasConceptScore W2013972997C2778165595 @default.
• W2013972997 hasConceptScore W2013972997C2778754761 @default.
• W2013972997 hasConceptScore W2013972997C2781300812 @default.
• W2013972997 hasConceptScore W2013972997C3017567848 @default.
• W2013972997 hasConceptScore W2013972997C42219234 @default.
• W2013972997 hasConceptScore W2013972997C71924100 @default.
• W2013972997 hasConceptScore W2013972997C98274493 @default.
• W2013972997 hasIssue "3" @default.
• W2013972997 hasLocation W20139729971 @default.
• W2013972997 hasLocation W20139729972 @default.
• W2013972997 hasOpenAccess W2013972997 @default.
• W2013972997 hasPrimaryLocation W20139729971 @default.
• W2013972997 hasRelatedWork W1975926347 @default.
• W2013972997 hasRelatedWork W1981153669 @default.
• W2013972997 hasRelatedWork W2014873458 @default.
• W2013972997 hasRelatedWork W2086776938 @default.
• W2013972997 hasRelatedWork W2135175115 @default.
• W2013972997 hasRelatedWork W2152483118 @default.
• W2013972997 hasRelatedWork W2347551417 @default.
• W2013972997 hasRelatedWork W2411512228 @default.
• W2013972997 hasRelatedWork W2412510091 @default.
• W2013972997 hasRelatedWork W3028769778 @default.

• next