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- W2013976476 abstract "It has been established that sleep deprivation (SD) reduces the proliferation of neuronal precursors in the adult hippocampus. It has also been reported that psychostimulant drugs modulate adult neurogenesis. We examined the modulatory role of two psychostimulant drugs modafinil and caffeine on adult neuronal cell proliferation (NCP) during 48 h of total SD. A novel automated cage shaking stimulus was used to induce SD based on animal activity. 5-Bromo-2″-deoxyuridine (BrdU; 50 mg/kg/day i.p.) was injected at the onset of the light phase for two days. Rats were successfully sleep deprived for 85–94% of total time. Stereological analysis showed that both caffeine and modafinil treatments during SD improved the number of BrdU positive cells as compared to the SD group. Caffeine treatment during SD, significantly increased early proliferative and post-mitotic stages of doublecortin (DCX) positive cells while modafinil treatment during SD, increased intermediate and post-mitotic stages of DCX positive cells compared to SD + Vehicle group. Brain-Derived Neurotrophic Factor (BDNF) expression on BrdU positive cells as well as in the dentate gyrus (DG) region was decreased significantly after sleep deprivation. Both caffeine and modafinil significantly improved BDNF expression in the DG region. Modafinil, but not caffeine, significantly decreased hippocampal adenosine level during SD in comparison to the SD + Vehicle group. It may be concluded that caffeine or modafinil treatment during 48 h of SD prevents the SD induced decline in neuronal proliferation and differentiation. Caffeine and modafinil induced alterations of NCP during SD may involve modulation of BDNF and adenosine levels." @default.
- W2013976476 created "2016-06-24" @default.
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- W2013976476 creator A5084362070 @default.
- W2013976476 creator A5089181048 @default.
- W2013976476 date "2013-10-01" @default.
- W2013976476 modified "2023-10-14" @default.
- W2013976476 title "Caffeine and modafinil promote adult neuronal cell proliferation during 48h of total sleep deprivation in rat dentate gyrus" @default.
- W2013976476 cites W1514696983 @default.
- W2013976476 cites W1521789748 @default.
- W2013976476 cites W1593725384 @default.
- W2013976476 cites W1664641772 @default.
- W2013976476 cites W1757080849 @default.
- W2013976476 cites W1866533950 @default.
- W2013976476 cites W1964239211 @default.
- W2013976476 cites W1964454256 @default.
- W2013976476 cites W1964468397 @default.
- W2013976476 cites W1968745677 @default.
- W2013976476 cites W1974477598 @default.
- W2013976476 cites W1977983363 @default.
- W2013976476 cites W1978890032 @default.
- W2013976476 cites W1979125819 @default.
- W2013976476 cites W1983069528 @default.
- W2013976476 cites W1983398247 @default.
- W2013976476 cites W1983686148 @default.
- W2013976476 cites W1984460802 @default.
- W2013976476 cites W1985050594 @default.
- W2013976476 cites W1986105622 @default.
- W2013976476 cites W1988538582 @default.
- W2013976476 cites W1990981339 @default.
- W2013976476 cites W1993476794 @default.
- W2013976476 cites W1995869250 @default.
- W2013976476 cites W1995995527 @default.
- W2013976476 cites W1997938089 @default.
- W2013976476 cites W2000269220 @default.
- W2013976476 cites W2005706069 @default.
- W2013976476 cites W2005932267 @default.
- W2013976476 cites W2006974714 @default.
- W2013976476 cites W2011245740 @default.
- W2013976476 cites W2013184659 @default.
- W2013976476 cites W2013825587 @default.
- W2013976476 cites W2014809682 @default.
- W2013976476 cites W2025375665 @default.
- W2013976476 cites W2025912164 @default.
- W2013976476 cites W2033795211 @default.
- W2013976476 cites W2035739069 @default.
- W2013976476 cites W2038571859 @default.
- W2013976476 cites W2039732070 @default.
- W2013976476 cites W2040273905 @default.
- W2013976476 cites W2040622315 @default.
- W2013976476 cites W2041639784 @default.
- W2013976476 cites W2045815714 @default.
- W2013976476 cites W2046908130 @default.
- W2013976476 cites W2047549885 @default.
- W2013976476 cites W2051430216 @default.
- W2013976476 cites W2051791532 @default.
- W2013976476 cites W2053349814 @default.
- W2013976476 cites W2053651413 @default.
- W2013976476 cites W2055803044 @default.
- W2013976476 cites W2060465478 @default.
- W2013976476 cites W2062920844 @default.
- W2013976476 cites W2065428236 @default.
- W2013976476 cites W2066118398 @default.
- W2013976476 cites W2067399440 @default.
- W2013976476 cites W2071937638 @default.
- W2013976476 cites W2073068789 @default.
- W2013976476 cites W2074994595 @default.
- W2013976476 cites W2077477890 @default.
- W2013976476 cites W2078740239 @default.
- W2013976476 cites W2079465999 @default.
- W2013976476 cites W2084451542 @default.
- W2013976476 cites W2089101964 @default.
- W2013976476 cites W2090240067 @default.
- W2013976476 cites W2090814539 @default.
- W2013976476 cites W2094483645 @default.
- W2013976476 cites W2095528375 @default.
- W2013976476 cites W2096232633 @default.
- W2013976476 cites W2096307371 @default.
- W2013976476 cites W2097078117 @default.
- W2013976476 cites W2101209448 @default.
- W2013976476 cites W2101478912 @default.
- W2013976476 cites W2112977759 @default.
- W2013976476 cites W2118399240 @default.
- W2013976476 cites W2122011624 @default.
- W2013976476 cites W2122924890 @default.
- W2013976476 cites W2124292257 @default.
- W2013976476 cites W2126845735 @default.
- W2013976476 cites W2127807410 @default.
- W2013976476 cites W2131575045 @default.
- W2013976476 cites W2135246609 @default.
- W2013976476 cites W2139378922 @default.
- W2013976476 cites W2140117942 @default.
- W2013976476 cites W2141008235 @default.
- W2013976476 cites W2142953327 @default.
- W2013976476 cites W2143723808 @default.